Alcohol Aids Cerebellar Deficit From Movement Disorder

This article originally appeared here.
Share this content:
Alcohol Aids Cerebellar Deficit From Movement Disorder
Alcohol Aids Cerebellar Deficit From Movement Disorder

THURSDAY, Sept. 21, 2017 (HealthDay News) -- Alcohol improves cerebellar-learning deficit in the movement disorder myoclonus-dystonia, according to a study published online Sept. 4 in the Annals of Neurology.

Anne Weissbach, M.D., from the University of Lübeck in Germany, and colleagues studied 17 myoclonus-dystonia patients with epsilon-sarcoglycan (SGCE) gene mutation and 21 age- and sex-matched healthy controls. Cerebellar associative learning and basal ganglia-brainstem interaction were assessed through classical eyeblink conditioning and blink reflex recovery cycle before and after alcohol intake resulting in a breath alcohol concentration of 0.08 percent.

The researchers found that patients showed a significantly reduced number of conditioned eyeblink responses before alcohol administration versus controls. In controls, the conditioning response rate decreased under alcohol intake, but in patients it increased (P = 0.004). The groups did not differ with respect to the blink reflex recovery cycle before and after alcohol intake. After alcohol intake, myoclonus improved significantly (P = 0.016). In patients, the severity of action myoclonus at baseline negatively correlated with the conditioning response in classical eyeblink conditioning.

"The combination of findings with reduced baseline acquisition of conditioned eyeblink responses and normal blink reflex recovery cycle in patients that improved significantly by alcohol intake suggests a crucial role of cerebellar networks in the generation of symptoms in these patients," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Phone-Based Intervention Aids Rheumatoid Arthritis Care

Educational phone calls with nurses promote shared decision making in care

Early PT Linked to Less Opioid Use in Musculoskeletal Pain

Early PT Linked to Less Opioid Use in ...

For opioid-naive patients, early physical therapy tied to less opioid use in shoulder, neck, knee, back pain

Emotional Stress of Holidays Can Trigger Heart Attacks

Emotional Stress of Holidays Can Trigger Heart Attacks

Higher risk seen on Christmas Eve, particularly in older adults with diabetes, heart disease

is free, fast, and customized just for you!




Already a member?

Sign In Now »