Albiglutide Beats Placebo for Cardiovascular Events in T2DM

Share this content:
Albiglutide Beats Placebo for Cardiovascular Events in T2DM
Albiglutide Beats Placebo for Cardiovascular Events in T2DM

THURSDAY, Oct. 4, 2018 (HealthDay News) -- For patients with type 2 diabetes and existing cardiovascular disease, albiglutide results in fewer cardiovascular events, according to a study published online Oct. 2 in The Lancet to coincide with the annual meeting of the European Association for the Study of Diabetes, held from Oct. 1 to 5 in Berlin.

Noting that in 2017, GlaxoSmithKline withdrew the glucagon-like peptide 1 (GLP-1) receptor agonist albiglutide for commercial reasons, Adrian F. Hernandez, M.D., from the Duke University School of Medicine in Durham, N.C., and colleagues presented the results from a randomized multicenter international trial involving albiglutide. Patients aged 40 years and older with type 2 diabetes and cardiovascular disease were randomly assigned to receive a subcutaneous injection of albiglutide or a matched volume of placebo (4,731 and 4,732 patients, respectively).

The intention-to-treat population was followed for a median of 1.6 years for the primary outcome. The researchers found that the primary composite outcome (first occurrence of cardiovascular death, myocardial infarction, or stroke) occurred in 7 and 9 percent of patients in the albiglutide and placebo groups, respectively (hazard ratio, 0.78), indicating that albiglutide was superior to placebo (P < 0.0001 for noninferiority; P = 0.0006 for superiority).

"Harmony-Outcomes was an important study for us to complete to generate new data and insights about the role of the GLP-1 receptor agonist class in the management of patients with diabetes and cardiovascular disease," John Lepore, M.D., from GlaxoSmithKline, said in a statement. "We continue to explore opportunities to divest this medicine to a company with the right expertise and resources to realize its full potential for patients."

Several authors disclosed financial ties to pharmaceutical companies, including GlaxoSmithKline, which funded the study.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Increase Seen in Salmonella Illnesses From Ground Beef

CDC: Increase Seen in <i>Salmonella</i> Illnesses From Ground ...

246 people now sickened; 59 people have been hospitalized; no deaths reported to date

Epinephrine Personal Autoinjectors Cost-Effective at 24

Epinephrine Personal Autoinjectors Cost-Effective at &#36;24

Based on 10-fold fatality risk difference, value-based price for personal epinephrine $24

Burden of Liver Cancer Rising in Medicare Patients

Burden of Liver Cancer Rising in Medicare Patients

Coexistence of other liver conditions tied to even higher risk for death, health care costs

is free, fast, and customized just for you!




Already a member?

Sign In Now »