Adjuvant Aripiprazole Beneficial in Tx-Resistant Depression

This article originally appeared here.
Share this content:
Adjuvant Aripiprazole Beneficial in Tx-Resistant Depression
Adjuvant Aripiprazole Beneficial in Tx-Resistant Depression

WEDNESDAY, Sept. 30, 2015 (HealthDay News) -- Adjuvant aripiprazole is associated with achievement of remission among older adults with treatment-resistant depression, according to a study published online Sept. 27 in The Lancet.

Eric J. Lenze, M.D., from the Washington University School of Medicine in St. Louis, and colleagues examined whether aripiprazole is associated with a higher probability of remission than placebo in adults aged older than 60 years with treatment-resistant depression. Participants were treated during a pre-trial with venlafaxine extended-release and those who did not achieve remission were randomized to the addition of aripiprazole (91 patients) or placebo (90 patients) for 12 weeks. Remission was assessed as the primary end point, and was defined as a Montgomery Asberg Depression Rating Scale score of 10 or less (and at least 2 points below the score at randomization).

The researchers found that a greater proportion of participants in the aripiprazole group versus the placebo group achieved remission (44 versus 29 percent; odds ratio, 2.0). The most common adverse effect of aripiprazole was akathisia (reported in 26 percent versus 1 percent in the placebo group). Aripiprazole also correlated with more Parkinsonism (17 versus 2 percent), but not with treatment-emergency suicidal ideation (21 versus 29 percent) or with other safety variables.

"The addition of aripiprazole is effective in achieving and sustaining remission," the authors write. "Tolerability concerns include the potential for akathisia and Parkinsonism."

Several authors disclosed financial ties to pharmaceutical companies, including Bristol-Myers Squibb, the manufacturer of aripiprazole.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Permits Marketing of Brain Stimulation Device for OCD

FDA Permits Marketing of Brain Stimulation Device for ...

FDA previously approved transcranial magnetic stimulation for major depression, certain migraines

Comments Open on End of NIH Review for Gene Therapy Studies

Comments Open on End of NIH Review for ...

NIH oversight panel no longer plans to review all applications for gene therapy experiments

U.S. Measles Outbreak Hits 107 Cases in 21 States, D.C.

U.S. Measles Outbreak Hits 107 Cases in 21 ...

Outbreak on track to exceed last year's; most of the people who got measles weren't vaccinated

is free, fast, and customized just for you!




Already a member?

Sign In Now »