Adaptive Servo-Ventilation No Benefit in Heart Failure

This article originally appeared here.
Share this content:
Adaptive Servo-Ventilation No Benefit in Heart Failure
Adaptive Servo-Ventilation No Benefit in Heart Failure

TUESDAY, Sept. 1, 2015 (HealthDay News) -- For patients with heart failure with reduced ejection fraction and predominantly central sleep apnea, adaptive servo-ventilation does not improve outcome, according to a study published online Sept. 1 in the New England Journal of Medicine to coincide with the annual European Society of Cardiology Congress, held from Aug. 29 to Sept. 2 in London.

Martin R. Cowie, M.D., from Imperial College London, and colleagues examined the impact of adaptive servo-ventilation in a trial involving 1,325 patients with a left ventricular ejection fraction of 45 percent or less, apnea-hypopnea index (AHI) of 15 or more events per hour, and a predominance of central events. Patients were randomized to receive guideline-based medical treatment with adaptive servo-ventilation or guideline-based medical treatment alone.

The researchers found that at 12 months, the mean AHI was 6.6 events per hour in the adaptive servo-ventilation group. There was no significant between-group difference in the incidence of the primary end point (54.1 percent in the adaptive servo-ventilation group and 50.8 percent in the control group; hazard ratio, 1.13; 95 percent confidence interval, 0.97 to 1.13; P = 0.10). The adaptive servo-ventilation group had significantly higher all-cause mortality and cardiovascular mortality than the control group.

"We found that in patients who had heart failure with a reduced ejection fraction and predominantly central sleep apnea, the addition of adaptive servo-ventilation to guideline-based medical treatment did not improve the outcome," the authors write.

Several authors disclosed financial ties to pharmaceutical and medical device companies, including ResMed, which funded the study.

Abstract
Full Text
Editorial
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Study Provides Estimates of U.S. Prevalence of Type 1, 2 Diabetes

Study Provides Estimates of U.S. Prevalence of Type ...

Prevalence of type 1 diabetes 0.5 percent, type 2 diabetes 8.5 percent among U.S. adults

Black Individuals at Highest Risk of Legal Intervention Injury

Black Individuals at Highest Risk of Legal Intervention ...

Increase in rates of injuries from 2005 to 2009, followed by a drop to 2015, returning to ~2005 levels

Research Links Doctor Burnout to Patient Safety Incidents

Research Links Doctor Burnout to Patient Safety Incidents

Physician burnout linked to increased risk of patient safety incidents, reduced patient satisfaction

is free, fast, and customized just for you!




Already a member?

Sign In Now »