Active Mind May Delay Alzheimer Symptoms, but Not Disease

This article originally appeared here.
Share this content:
Active Mind May Delay Alzheimer Symptoms, but Not Disease
Active Mind May Delay Alzheimer Symptoms, but Not Disease

THURSDAY, Feb. 25, 2016 (HealthDay News) -- Intellectual enrichment (high education and high midlife cognitive activity) has effects on biomarkers of Alzheimer's disease (AD) in older adults, according to a study published online Feb. 24 in Neurology.

Prashanthi Vemuri, Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues examined the effect of age, sex, APOE4 genotype, and lifestyle enrichment on AD biomarker trajectories. Data were included for 393 participants without dementia from the Mayo Clinical Study of Aging (age 70 years and older) who had cognitive and physical activity measures and two or more visits with imaging biomarkers. Imaging data included brain β-amyloid load via Pittsburgh compound B positron emission tomography (PET) and neurodegeneration via 18fluorodeoxyglucose (FDG) PET and magnetic resonance imaging. The population was dichotomized into high (≥14 years) and low (<14 years) education levels.

The researchers found that age correlated with amyloid and neurodegeneration trajectories. The amyloid and FDG trajectories, but not the hippocampal volume trajectory were influenced by APOE4 status. High midlife cognitive activity correlated with lower amyloid deposition in APOE4 carriers in the high-education stratum. In the entire cohort, and in participants with lower education, APOE4 status correlated with lower FDG uptake.

"There were minimal effects of lifestyle enrichment on AD biomarker trajectories (specifically rates)," the authors write. "Differing education levels may explain the conflicting results seen in the literature."

Several authors disclosed financial ties to the pharmaceutical and medical technology industries.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ancient Gene Protects Elephants From Cancer

Ancient Gene Protects Elephants From Cancer

The LIF6 gene destroys cells with damaged DNA

Reasons for Undergoing Cosmetic Procedures Explored

Reasons for Undergoing Cosmetic Procedures Explored

Psychological and emotional motivations more likely in patients wanting acne scar tx, tattoo removal

DNR Orders Linked to Increased Mortality in Older Adults

DNR Orders Linked to Increased Mortality in Older ...

Early versus late DNR tied to shorter median length of stay in hospitalized adults aged 65 years and older

is free, fast, and customized just for you!




Already a member?

Sign In Now »