ACC: Carvedilol Doesn't Prevent Anthracycline Cardiotoxicity

Share this content:
ACC: Carvedilol Doesn't Prevent Anthracycline Cardiotoxicity
ACC: Carvedilol Doesn't Prevent Anthracycline Cardiotoxicity

MONDAY, March 12, 2018 (HealthDay News) -- For women with human epidermal growth factor receptor type 2 (HER2)-negative breast cancer receiving anthracycline (ANT) chemotherapy, carvedilol does not prevent cardiotoxicity, according to a study published online March 11 in the Journal of the American College of Cardiology. The research was published to coincide with the annual meeting of the American College of Cardiology, held from March 10 to 12 in Orlando, Fla.

Monica Samuel Avila, M.D., from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo in Brazil, and colleagues examined the role of carvedilol in preventing ANT cardiotoxicity in patients with HER2-negative breast cancer tumor status and normal left ventricular ejection fraction (LVEF). Two hundred patients referred for ANT were randomized to receive carvedilol or placebo until completion of chemotherapy.

The researchers found that the primary end point of prevention of a ≥10 percent reduction in LVEF at six months occurred in 14.5 and 13.5 percent of patients in the carvedilol and placebo groups, respectively (P = 1.0). There were no differences between the groups in changes of LVEF or brain natriuretic peptide. Troponin I levels differed significantly between the groups over time, with the carvedilol group having lower levels (P = 0.003). The carvedilol group also had a significantly lower incidence of diastolic dysfunction (P = 0.039).

"In this scenario, carvedilol had no impact on the incidence of early onset of LVEF reduction," the authors write.

Baldacci Laboratories donated the carvedilol and placebo used in this study.

Abstract/Full Text (subscription or payment may be required)
More Information

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Trending Activities

All Professions

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Ground Beef Recalled After E. Coli Outbreak

Ground Beef Recalled After <i>E. Coli</i> Outbreak

Beef was produced and packaged at Cargill Meat Solutions in Fort Morgan, Colo.

Prevalence of Alzheimer's, Related Dementia Set to Double

Prevalence of Alzheimer's, Related Dementia Set to Double

Alzheimer's disease and related dementias burden is expected to increase to 3.3 percent in 2060

Long-Term Outcomes of Breast Implants Explored

Long-Term Outcomes of Breast Implants Explored

Higher rates of Sjogren syndrome, scleroderma, RA, stillbirth, melanoma for silicone implants

is free, fast, and customized just for you!




Already a member?

Sign In Now »