Abnormalities in Genes Linked to IRSP in Alzheimer's Disease

Share this content:
Abnormalities in Genes Linked to IRSP in Alzheimer's Disease
Abnormalities in Genes Linked to IRSP in Alzheimer's Disease

MONDAY, Nov. 5, 2018 (HealthDay News) -- Individuals with Alzheimer's disease (AD) have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway (IRSP), according to a study published online Nov. 1 in PLOS ONE.

Pavel P. Katsel, Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined IRSP and endothelial cell markers in the parahippocampal gyrus of 30 controls, 19 individuals with AD, and 34 individuals with AD and type 2 diabetes (T2D) who had been treated with anti-diabetic drugs. The gene expression of selected members of the IRSP and selective endothelial cell markers were examined in bulk postmortem tissue from the parahippocampal gyrus and in endothelial cell-enriched isolates from the same brain region.

The researchers found that in the parahippocampal gyri of persons with AD, there were considerable abnormalities and reductions in gene expression, which map directly to genes associated with the microvasculature and the IRSP. There was a significant reduction in the numbers of abnormally expressed microvasculature and IRSP-associated genes in individuals with AD with T2D who had been treated with anti-diabetic agents.

"Given the dual epidemics of T2D and dementia in the most rapidly growing segment of our population, there is enormous importance in elucidating the basis for cognitive impairment in T2D so that potentially meaningful interventions can be evaluated," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC: Progress in HIV Prevention Has Stalled in the United States

CDC: Progress in HIV Prevention Has Stalled in ...

Agency says effective HIV prevention, treatment not reaching those who could most benefit

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in Children

AAAAI: Egg Oral Immunotherapy Shows Sustained Benefit in ...

All children with sustained unresponsiveness ingested concentrated and baked egg

Prenatal Vitamin Intake in Early Pregnancy May Cut Autism Risk

Prenatal Vitamin Intake in Early Pregnancy May Cut ...

ASD risk down for children whose mothers took prenatal vitamins during first month of pregnancy

is free, fast, and customized just for you!




Already a member?

Sign In Now »