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From Pathways to PROs: Translating the Latest Evidence for Current and Emerging JAK Inhibitors to Clinical Practice

From Pathways to PROs: Translating the Latest Evidence for Current and Emerging JAK Inhibitors to Clinical Practice

Format

Webcast

Time to Complete

1.50 hours

Released

December 27, 2018

Expires

December 27, 2019
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Maximum Credits

1.50 / AMA PRA Category 1 CreditsTM
1.50 / ABIM MOC Points
1.50 / CNE Contact Hours
1.50 / CE for Pharmacists (0.15 CEUs)

Accredited Provider



This educational initiative is provided by CME Outfitters.

Commercial Supporter

Supported by an educational grant from Gilead Sciences, Inc.

Program Description

Current therapeutic approaches for RA rely on disease-modifying antirheumatic drugs (DMARDs) as well as on biologic therapeutics that target tumor necrosis factor (TNF), interleukin-6 (IL-6), and T cell activation or that eliminate CD20+ B cells. These treatments have limitations, such as waning efficacy over time, side effects, and dosing inconvenience. Clinicians need to be aware of what other treatment options exist or are emerging. Further, rheumatology clinicians often face challenges in translating clinical evidence and data to real-world practice, and assessing the role of patient-reported outcomes (PROs) is pertinent when determining the value of new therapeutics for RA.

This CME Outfitters enduring material, featuring expert faculty discussion and learner interactivity, will address gaps related to emerging discoveries of inflammatory targets, clinical trial data, and the role of patient-reported outcomes (PROs) in practice, with resources posted to the Rheumatology Digital Hub.

Intended Audience

Rheumatologists, primary care physicians, nurse practitioners, physician assistants, nurses, and pharmacists who treat patients with rheumatoid arthritis.

Educational Objectives

At the end of this CME/CE activity, participants should be able to:

Physicians/PAs

  • Translate basic clinical immunology to current evidence for the pathophysiology and MOA for current and emerging JAK inhibitors.
  • Evaluate clinical trial data for emerging small molecule/intracellular signaling targets in the management of patients with rheumatoid arthritis.
  • Assess the role of patient-reported outcomes (PROs) as measures for the value of new therapeutics for RA, in addition to safety and efficacy data.

CNE/CPE

  • Translate basic clinical immunology to current evidence for the pathophysiology and MOA for current and emerging JAK inhibitors.
  • Evaluate clinical trial data for emerging small molecule/intracellular signaling targets in the management of patients with rheumatoid arthritis (RA).
  • Assess the role of patient-reported outcomes (PROs) as measures for the value of new therapeutics for RA, in addition to safety and efficacy data.

Conflict Of Interest Disclosure Policy

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CE activity. CME Outfitters, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Faculty

Stanley B. Cohen, MD
Clinical Professor, Department of Internal Medicine
University of Texas Southwestern Medical School
Co-Director, Division of Rheumatology
Presbyterian Hospital, Dallas
Co-Medical Director
Metroplex Clinical Research Center
Dallas, TX
Past President of the American College of Rheumatology
Atlanta, GA

Dr. Cohen reports that he is a clinical investigator and/or research consultant for AbbVie Inc.; AstraZeneca; Biogen Idec Inc.; Bristol-Myers Squibb Company; Genentech, Inc.; Janssen Pharmaceuticals, Inc.; Eli Lilly and Company; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Merck & Co., Inc.; F. Hoffmann-La Roche Ltd.

Leonard H. Calabrese, DO
Professor of Medicine
Vice Chair, Department of Rheumatic & Immunologic Disease
Cleveland Clinic Lerner College of Medicine
of Case Western Reserve University
R.J. Fasenmyer Chair of Clinical Immunology
Cleveland Clinic Foundation
Cleveland, OH

Dr. Calabrese reports that he is a consultant for AbbVie Inc.; Centocor Biopharmaceutical; Crescendo Bioscience, Inc.; GlaxoSmithKline; Horizon Pharma; Janssen Pharmaceuticals, Inc.; Pfizer Inc.; Regeneron Pharmaceuticals, Inc.; UCB, Inc.

Accredited Provider Disclosure

The CME Outfitters, LLC staff has nothing to disclose.

Planners' and Managers' Disclosures

Jeffrey Helfand, DO, MS, (peer reviewer) has no disclosures to report.
Mae Ochoa, RPh, (peer reviewer) has no disclosures to report.
Kate Nelson, PHD, (planning committee) has no disclosures to report
Sharon Tordoff (planning committee) has no disclosures to report.
Jan Perez (planning committee) has no disclosures to report.

Credit

1.50

Type

AMA PRA Category 1 Credit(s)TM

Accreditation Statement

CME Outfitters, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation Statement

CME Outfitters, LLC, designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM  . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Credit

1.50

Type

AMA PRA Category 1 Credit(s)TM /ABIM MOC point(s)

Accreditation Statement

CME Outfitters, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation Statement

CME Outfitters, LLC, designates this enduring material for a maximum of 1.50 AMA PRA Category 1 CreditsTM  . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ABIM MOC Part II Points:
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.50 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Credit

1.50

Type

CNE Contact Hour(s)

Accreditation Statement

CME Outfitters, LLC, is approved by the California Board of Registered Nursing.

Designation Statement

Provider approved by the California Board of Registered Nursing, Provider Number CEP 15510, for 1.50 contact hours

Credit

1.50

Type

CE for Pharmacists

Accreditation Statement

CME Outfitters, LLC, is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.1.50 contact hours (0.15 CEUs)

Universal Activity Number: 0376-0000-18-020-H01-P

Type: Knowledge-based

Additional Credit Information

Note to Nurse Practitioners: Nurse practitioners can apply for AMA PRA Category 1 CreditTM   through the American Academy of Nurse Practitioners (AANP). AANP will accept AMA PRA Category 1 CreditTM   from organizations accredited by the Accreditation Council for Continuing Medical Education. Nurse practitioners can also apply for credit through their state boards.

Note to Physician Assistants: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 CreditTM   from organizations accredited by the Accreditation Council for Continuing Medical Education.

MIPS Improvement Activity: This activity counts towards MIPS Improvement Activity requirements under the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). Clinicians should submit their improvement activities by attestation via the CMS Quality Payment Program website.

Disclosure of Unlabeled Use

Faculty of this CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. The faculty have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management.

Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Instructions

There are no fees for participating in this CME/CE activity. To receive credit, participants must (1) read the learning objectives and disclosure statements, (2) study the educational activity, and (3) complete the post-test and activity evaluation form, including the certificate information section.

To obtain a certificate, participants must receive a score of 75% or better on the post-test. The post-test can be accessed at the end of the activity. Your online certificate will be saved on myCME within your Profile/CME History, which you can access at any time.

If you have any questions relating to the accreditation of this activity, please contact CME Outfitters at 877-263-7767.

If you have any other questions relating to your certificate or other issues with this activity, please contact myCME.Support@haymarketmedical.com.

SYSTEM REQUIREMENTS

Hardware and Software Requirements
  • A computer with an internet connection
  • Internet Browser: Internet Explorer 7.x or higher, Firefox 4.x or higher, Safari 2.x or higher, or any other W3C standards compliant browser
  • Additional Software: Adobe Flash Player and/or an HTML 5 capable browser maybe required for video or audio playback. PowerPoint or Adobe Acrobat Reader may occasionally be required
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