1.25 / AMA PRA Category 1 CreditTM 1.25 / Pharmacy CE Contact Hours (0.125 CEUs)
This activity is jointly provided by Purdue University College of Pharmacy and CiME.
Supported by an educational grant from Mallinckrodt Pharmaceuticals
Hepatorenal syndrome (HRS) describes the reversible, functional renal impairment that occurs in patients who have advanced cirrhosis, arising portal hypertension, and/or those with fulminant hepatic failure. Most commonly encountered as acute kidney injury (AKI) in patients with decompensated cirrhosis, HRS is characterized by a reduction in glomerular filtration rate and renal plasma flow, in the absence of other causes of AKI. Prognosis is poor, with high mortality rates, and there are currently no approved pharmacotherapies to ameliorate the effects of HRS in the US.
This activity will discuss new information and approaches to identifying patients with or at risk for HRS; the application of evidence-based algorithms to the pharmacologic and surgical options for patients with suspected HRS, and shortening time to application of therapeutic interventions to maximize patient survival rates and outcomes.
Hepatologists, Gastroenterologists, Nephrologists, Critical Care Medicine specialists
After completing this activity, participants should be better able to:
Describe the pathophysiology of acute kidney injury including hepatorenal syndrome in cirrhosis
Discuss the new diagnostic criteria for AKI/HRS in cirrhosis and definitions for response to treatment for AKI
Identify the appropriate timing of referral of patients with cirrhosis to a tertiary treatment center for evaluation and management for AKI/HRS
Evaluate the various treatment options available for AKI/HRS
Identify predictive factors for treatment response
Accreditor Disclosure of Conflicts of Interest Policy
It is the policy of both Purdue University College of Pharmacy and CiME to ensure independence, balance, objectivity, scientific rigor, and integrity in all their continuing education activities. All faculty, staff and reviewers involved in the planning, review or presentation of continuing education activities provided by Purdue University College of Pharmacy are required to disclose to the audience any relevant commercial financial affiliations related to the content of the presentation or enduring material. Full disclosure of all commercial relationships must be made in writing to the audience prior to the activity. Identified conflict of interest is resolved by Purdue University College of Pharmacy prior to accreditation of the activity.
ACTIVITY CHAIRPERSON Florence Wong, MBBS, MD, FRACP, FRCPC Professor, Division of Gastroenterology Department of Medicine University of Toronto Toronto, Ontario, Canada
Dr. Wong reports the following disclosures: Mallinckrodt (Grants/Research Support; Consultant; Honoraria Received)
FACULTY Guadalupe Garcia-Tsao, MD Professor of Medicine Chief, Digestive Diseases, VA-CT Healthcare System Director, Clinical and Translational Core, Yale Liver Center Program Director, VA-CT Hepatitis C Resource Center Yale School of Medicine New Haven, Connecticut
Hugo E. Vargas, MD Professor of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine Mayo Clinic Phoenix, Arizona
Dr. Vargas reports the following disclosures: American Journal of Gastroenterology (Editorial Board); Enterome (Advisory Board); Grifols (Grants/Research Support); Mallinckrodt (Grants/Research Support); Transmedics (Data Safety Monitoring Board); Verily (Grants/Research Support)
AMA PRA Category 1 Credit(s)TM
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Purdue University College of Pharmacy and CiME. Purdue University College of Pharmacy, an equal access/equal opportunity institution, is accredited by the ACCME to provide continuing medical education for physicians.
Purdue University College of Pharmacy designates this enduring activity for a maximum of 1.25 AMA PRA Category 1 CreditTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity.
CE for Pharmacists
Purdue University College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This is a knowledge based, continuing education activity of Purdue University, an equal access/equal opportunity institution.
Purdue University College of Pharmacy designates this enduring activity for a maximum of 1.25 Contact Hours (0.125 CEUs).
All additional planning committee members, staff and reviewers of CiME and Purdue University College of Pharmacy have no relationships to disclose.
Disclosure of Unlabeled Use
This activity contains information of commercial products/devices that are unlabeled for use or investigational uses of products not yet approved. There is currently no pharmacologic agent approved by the US FDA for the treatment of HRS.
The views expressed in this activity are those of the faculty. It should not be inferred or assumed that they are expressing the views of the commercial supporter, any other manufacturer of pharmaceuticals or devices, Purdue University College of Pharmacy, or CiME.
It should be noted that the recommendations made herein with regard to the use of therapeutic agents, varying disease states, and assessments of risk are based upon a combination of clinical trials, current guidelines, and the clinical practice experience of the participating presenters. The drug selection and dosage information presented in this activity are believed to be accurate. However, participants are urged to consult all available data on products or procedures before using them in clinical practice.
To obtain credit, a score of 70% or better on the post-test is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a digital copy of your credit certificate. Your online certificate will be saved on myCME within your Profile/CME History, which you can access at any time.