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DUAKLIR PRESSAIR
Asthma/COPD
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Drug Name:

DUAKLIR PRESSAIR Rx

Generic Name and Formulations:
Aclidinium bromide 400mcg, formoterol fumarate 12mcg; per actuation; dry powder for oral inhalation.

Company:
Circassia Pharmaceuticals Inc.

Therapeutic Use:

Indications for DUAKLIR PRESSAIR:

Maintenance treatment of COPD.

Limitations Of use:

Not indicated for relief of acute bronchospasm or for treatment of asthma.

Adult:

1 inhalation twice daily (in the AM + PM). Max 1 inhalation twice daily.

Children:

Not established.

Contraindications:

Use of LABA without inhaled corticosteroid (ICS) in asthma. Milk protein sensitivity.

Warnings/Precautions:

LABA as monotherapy (without ICS) for asthma can increase risk of asthma-related events. Do not initiate in acute deteriorating COPD. Not for relief of acute symptoms. Prescribe a short-acting β2-agonist for acute symptoms; monitor for increased need. Do not exceed recommended dose. Discontinue immediately and treat if paradoxical bronchospasm or immediate hypersensitivity reactions occur; use alternative therapy. Cardiovascular disorders (eg, coronary insufficiency, cardiac arrhythmias, hypertension). Convulsive disorders. Thyrotoxicosis. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Hypokalemia. Hyperglycemia. Narrow-angle glaucoma. Urinary retention. Prostatic hyperplasia. Bladder-neck obstruction. Pregnancy. Labor & delivery. Nursing mothers.

Pharmacological Class:

Anticholinergic + long-acting beta-2 agonist (LABA).

Interactions:

Caution with concomitant other adrenergic drugs; may potentiate sympathetic effects. Concomitant xanthine derivatives, steroids, or diuretics may potentiate hypokalemia. Caution with non-K+-sparing diuretics. Extreme caution with MAOIs, tricyclics, or others that prolong QTc interval. Antagonized by β-blockers; if needed, use cardioselective agents if no acceptable alternatives. Additive effects with concomitant other anticholinergic-containing drugs; avoid.

Adverse Reactions:

Upper respiratory tract infection, headache, back pain; paradoxical bronchospasm, hypersensitivity reactions, cardiovascular effects.

Generic Availability:

NO

How Supplied:

Dry powder inhaler—30, 60 doses

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