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Deciphering The Tumor Genome: Exploring Molecular and Clinical Advances in the DNA Damage Response Pathway

Deciphering The Tumor Genome: Exploring Molecular and Clinical Advances in the DNA Damage Response Pathway

Format

Slide Lecture Series

Time to Complete

1 hour

Released

January 23, 2019

Expires

April 23, 2019
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Maximum Credits

1.00 / AMA PRA Category 1 Credit(s)TM
1.00 / CNE Contact Hour

Accredited Provider



This activity is provided by Creative Educational Concepts.

Commercial Supporter

This activity is supported by an educational grant from AstraZeneca.

Program Description

Our understanding of underlying genetic mechanisms that drive tumorigenesis has exponentially increased over the last several years. As a result, there has been an ever-growing shift in the treatment paradigm for various cancer types, many of which have focused on personalized therapies that exploit vulnerabilities in tumor DNA. Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated efficacy in BRCA-mutated tumors (i.e., ovarian, breast, prostate, and pancreatic), as well as in those with other genes defective in the DNA damage repair pathway. While the introduction of such targeted therapies has dramatically expanded treatment options for cancer patients, it also has introduced complexities to clinical decision making and care, including the selection of patients for genetic testing, appropriate timing of testing, and interpretation of genetic information. As the use of precision therapy and accompanying diagnostics are increasingly incorporated into the future of cancer care, clinicians involved in genetic testing and counseling will become increasingly essential to the oncology team and will play a major role in the care of cancer patients.

Intended Audience

Genetic counselors, medical and clinical geneticists, laboratory researchers, nurses, physicians, physician assistants, and all medical practitioners who are involved in the diagnosis, management, and genetic counseling of patients who have or are at risk for DDR-mutated cancers.

Educational Objectives

Upon completion of this activity, participants will be able to:

  • Outline the role of the DNA damage response (DDR) pathway in tumor suppression and describe how mutations in DDR genes lead to tumor proliferation.
  • Explore recent advances in the discovery of actionable mutations in DDR (e.g., BRCA1/2) and the developments in precision medicine targeting these mutations, including poly (ADP-ribose) polymerase (PARP) inhibitors.
  • Assess current guideline recommendations for genetic testing and counseling in patients with possible or known pathogenic DNA damage response mutations.
  • Using a case-based approach, evaluate challenging questions encountered in the genetic testing and counseling of BRCA1/2 and other DDR mutations, and discuss the evolving role of the genetic counselor in the interprofessional oncology care team.

Conflict Of Interest Disclosure Policy

In accordance with the Food and Drug Administration, the authors have disclosed that there is the potential for discussions concerning off-label uses of a commercial product/device during this educational activity.

Any person who may contribute to the content of this continuing education activity must disclose relevant relationships (and any known relationships of their spouse/partner) with commercial interests whose products or services are discussed in educational presentations. A commercial interest is defined as an entity producing, marketing, re-selling, or distributing healthcare goods or services consumed by, or used on patients. Relevant relationships include receiving from a commercial interest research grants, consultant fees, travel, other benefits, or having a self-managed equity interest in a company.

Disclosure of a relationship is not intended to suggest or condone any bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation.

Faculty

Justine Pickarski, MS, LGC
Certified Genetic Counselor
University of Kentucky
Markey Cancer Center
Lexington, KY

Ms. Pickarski has no relevant financial relationships to disclose in relation to the content of this activity.

Nadine Tung, MD
Chief, Breast Oncology
Director, Cancer Genetics and Prevention Program
Beth Israel Deaconess Medical Center
Associate Professor of Medicine
Harvard Medical School

Dr. Tung has no relevant financial relationships to disclose in relation to the content of this activity.

Planners and Reviewers Disclosures

Planners
Vanessa Carranza, PharmD
, has no relevant financial relationships to disclose in relation to the content of this activity.

Peer Reviewers
Susan H. Scher, MD
, has no relevant financial relationships to disclose in relation to the content of this activity.
Paula J. Anastasia, has disclosed that she is a consultant for Clovis and Genentech.

Credit

1.00

Type

AMA PRA Category 1 Credit(s)TM

Accreditation Statement

In support of improving patient care, Creative Educational Concepts is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Designation Statement

CEC designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)TM  .  Physicians should only claim credit commensurate with the extent of their participation in the activity.

Credit

1.00

Type

CNE Contact Hour(s)

Accreditation Statement

In support of improving patient care, Creative Educational Concepts is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Designation Statement

This activity is designated for 1.00 contact hour.

Learners are advised that accredited status does not imply endorsement by the provider or ANCC of any commercial products displayed in conjunction with an activity.

Disclosure of Unlabeled Use

This activity may include discussions of products or devices that are not currently approved for use by the Food and Drug Administration (FDA), or are currently investigational.

Disclaimer

It is the policy of CEC to ensure independence, balance, objectivity, scientific rigor, and integrity in their continuing education activities.

Those involved in the development of this continuing education activity have made all reasonable efforts to ensure that information contained herein is accurate in accordance with the latest available scientific knowledge at the time of accreditation of this continuing education activity. Information regarding drugs (e.g., their administration, dosages, contraindications, adverse reactions, interactions, special warnings, and precautions) and drug delivery systems is subject to change, however, and the learner is advised to check the manufacturer's package insert for information concerning recommended dosage and potential problems or cautions prior to prescribing, dispensing, or administering the drug or using the drug delivery systems.

Fair balance is achieved through ongoing and thorough review of all presentation materials produced by faculty, and all educational and advertising materials produced by supporting organizations, prior to educational offerings. Approval of credit for this continuing education activity does not imply endorsement by CEC for any product or manufacturer identified.

Instructions

To obtain credit, a score of 70% or better on the post-test is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a digital copy of your credit certificate. Your online certificate will be saved on myCME within your Profile/CME History, which you can access at any time.

If you have any questions relating to the accreditation of this activity, please contact Creative Educational Concepts at (866) 360-1717.

If you have any other questions relating to your certificate or other issues with this activity, please contact myCME.Support@haymarketmedical.com.

SYSTEM REQUIREMENTS

Hardware and Software Requirements
  • A computer with an internet connection
  • Internet Browser: Internet Explorer 7.x or higher, Firefox 4.x or higher, Safari 2.x or higher, or any other W3C standards compliant browser
  • Additional Software: Adobe Flash Player and/or an HTML 5 capable browser maybe required for video or audio playback. PowerPoint or Adobe Acrobat Reader may occasionally be required
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