As the population ages, osteoporosis has become an increasingly important public health threat for both women and men. This debilitating, potentially deadly, and costly disorder affects nearly 1 in 3 women and 2 in 10 men by age 50 years—and almost 8 in 10 women by age 80 years and older, with the risk of fragility fracture increasing with age. While more women than men have osteoporosis, the absolute number of men with osteoporosis is nonetheless high, and men experience poorer outcomes and higher risk for mortality. Nevertheless, awareness of the need for osteoporosis screening remains low, even among individuals who are at high risk. In this Case Clinic centered on a male patient, a noted expert provides tips on how to recognize patients at risk and outlines practical and cost-effective recommendations on screening and assessment to help prevent fractures and improve health outcomes.