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Case Clinic 1: A 61-Year-Old Woman Previously Treated for HCV Genotype 1a

Case Clinic 1: A 61-Year-Old Woman Previously Treated for HCV Genotype 1a


Patient Case Study

Time to Complete

30 minutes


September 28, 2017


September 28, 2018
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Maximum Credits

0.50 / AMA PRA Category 1 CreditTM

Accredited Provider

This educational activity is provided by the American Gastroenterological Association.

Commercial Supporter

Supported by an educational grant from Merck & Co., Inc.


Produced by Haymarket Medical Education (HME)

Program Description

In this Case Clinic, Bruce Bacon, MD, discusses the management of a 61-year-old woman with type 2 diabetes mellitus, hypertension, and an elevated body mass index who was unsuccessfully treated for hepatitis C virus (HCV) infection with an interferon-based regimen 15 years ago. Recent testing has revealed HCV genotype 1a and advanced fibrosis; she also is positive for NS5A resistance. The case discussion highlights how findings of resistance and advanced fibrosis affect management as well as the importance of post-treatment surveillance for hepatocellular carcinoma.

Intended Audience

Gastroenterologists, hepatologists, primary care clinicians, and other providers who treat patients with hepatitis C

Educational Objectives

At the conclusion of this activity, participants should be better able to:

  • Select the appropriate direct-acting antiviral (DAA) agent for hepatitis C virus (HCV) infection based on viral genotypes (and subtype) and associated complications
  • Implement strategies, including the spectrum of molecular testing protocols, to identify and monitor disease progression and treatment efficacy and potentially avert HCV treatment resistance
  • Facilitate better linkage of care among specialists and other providers to strengthen screening, treatment, and monitoring practices, particularly for underserved and marginalized populations

Conflict Of Interest Disclosure Policy

In accordance with the ACCME’s Standards for Commercial Support of Continuing Medical Education, all faculty and planning partners must disclose any financial relationship(s) or other relationship(s) held within the past 12 months. The AGA Institute implements a mechanism to identify and resolve all conflicts of interest prior to delivering the educational activity to learners.


Bruce Bacon, MD
Professor of Internal Medicine
James F. King Endowed Chair in Gastroenterology
Saint Louis University School of Medicine
St. Louis, MO

Dr. Bacon receives consulting fees from AbbVie Inc., Gilead Sciences, Inc., and Intercept Pharmaceuticals, Inc., and sits on the advisory committee for Merck & Co., Inc.

Accredited Provider and Publishing Staff Disclosures

No other individuals involved with planning and delivering the content disclosed any relevant financial relationships.




AMA PRA Category 1 Credit(s)TM

Accreditation Statement

The AGA Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation Statement

The AGA Institute designates this enduring activity for a maximum of 0.50 AMA PRA Category 1 CreditTM  . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of approved and/or investigational uses of agents that are not indicated by the FDA. AGA Institute, Haymarket Medical Education, and Merck & Co., Inc., do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AGA Institute, Haymarket Medical Education, and Merck & Co., Inc. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


AGA Institute does not provide any warranty as to the accuracy or reliability of information presented either verbally or in writing by presenters. No responsibility is assumed by AGA Institute for any injury and/or damage to persons or property resulting from any use of such information.

If you have any questions relating to the accreditation of this activity, please contact the AGA education department at or 301-654-2055.


To obtain credit, a score of 70% or better on the post-test is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a digital copy of your credit certificate. Your online certificate will be saved on myCME within your Profile/CME History, which you can access at any time.

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