Generic Name and Formulations:
Acetazolamide 500mg/vial; pwd for inj after reconstitution; preservative-free.
Various generic manufacturers
Give by IV inj. Edema: give 1–2 days on, 1 day off. 250mg–375mg once daily. CHF: 250–375mg once daily in the AM. Acute high altitude sickness: see literature.
Hypokalemia. Hyponatremia. Severe renal, hepatic, or adrenocortical impairment. Hyperchloremic acidosis. Cirrhosis. Chronic noncongestive angle-closure glaucoma. Sulfonamide allergy.
Respiratory impairment. Renal calcium calculi. Diabetes. Gout. Monitor blood and electrolytes. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Carbonic anhydrase inhibitor.
Inhibits renal excretion of basic drugs and promotes excretion of acidic drugs. May increase toxicity of salicylates (acidosis), folic acid antagonists. Hypokalemia with corticosteroids, potassium wasting diuretics. Monitor phenytoin, primidone, antihyperglycemics, quinidine, lithium, cyclosporine. Antagonizes methenamine.
Anorexia, drowsiness, confusion, malaise, depression, GI distress, paresthesias, tinnitus, acidosis, initial hypokalemia, hyperuricemia, transient myopia; renal calculi, nephrotoxicity, hepatic dysfunction, blood dyscrasias, rash, fever, photosensitivity (rare).
Formerly known under the brand name Diamox.
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