Viral Infection of Engrafted Human Islets Leads to Diabetes

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Type 1 diabetes (T1D) is characterized by the destruction of the insulin-producing -cells of pancreatic islets. Viral infection with enteroviruses is a suspected trigger for T1D but a causal role remains unproven and controversial. In order to resolve the controversial role of viruses in human T1D, we developed a viral infection model in immunodeficient mice bearing human islet grafts.
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