RhoA Signaling in Cardiomyocytes Protects Against Stress-Induced Heart Failure But Facilitates Cardiac Fibrosis

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RhoA Signaling in Cardiomyocytes Protects Against Stress-Induced Heart Failure But Facilitates Cardi
RhoA Signaling in Cardiomyocytes Protects Against Stress-Induced Heart Failure But Facilitates Cardi
The Ras-related guanosine triphosphatase RhoA mediates pathological cardiac hypertrophy, but also promotes cell survival and is cardioprotective after ischemia/reperfusion injury. To understand how RhoA mediates these opposing roles in the myocardium, we generated mice with a cardiomyocyte-specific deletion of RhoA.
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