Zoledronic Acid Every 12 Weeks Noninferior in Bone Metastases

Share this content:
Zoledronic Acid Every 12 Weeks Noninferior in Bone Metastases
Zoledronic Acid Every 12 Weeks Noninferior in Bone Metastases

TUESDAY, Jan. 3, 2017 (HealthDay News) -- Use of zoledronic acid every 12 weeks does not result in increased risk of skeletal events compared with use every four weeks among patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma, according to a study published in the Jan. 3 issue of the Journal of the American Medical Association.

Andrew L. Himelstein, M.D., from the Helen F. Graham Cancer Center & Research Institute in Newark, Del., and colleagues randomized 1,822 patients with metastatic breast cancer, metastatic prostate cancer, or multiple myeloma with at least one site of bone involvement to receive zoledronic acid administered intravenously every four weeks or every 12 weeks (911 each) for two years. Of the patients, 795 completed the study at two years.

The researchers found that 29.5 and 28.6 percent of patients in the zoledronic acid four-week and 12-week groups, respectively, experienced at least one skeletal-related event within two years of randomization (risk difference, −0.3 percent; P < 0.001 for noninferiority). The proportions of skeletal-related events did not differ between the groups for patients with breast cancer, prostate cancer, or multiple myeloma. Between the treatment groups there was no significant difference in pain scores, performance status scores, incidence of jaw osteonecrosis, and kidney dysfunction. Both groups had numerically identical skeletal morbidity rates, but greater turnover was seen among patients who received zoledronic acid every 12 weeks.

"This longer interval may be an acceptable treatment option," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Approves Zejula for Certain Female Cancers

FDA Approves Zejula for Certain Female Cancers

PARP inhibitor may help fight tumors affecting the ovaries, fallopian tubes, or peritoneum

USPSTF: Evidence Lacking for Celiac Dz Screen in Asymptomatic

USPSTF: Evidence Lacking for Celiac Dz Screen in ...

Insufficient evidence for weighing benefits, harms of screening for celiac disease in asymptomatic

Lap, Abdominal Hysterectomy Equal for Early Endometrial CA

Lap, Abdominal Hysterectomy Equal for Early Endometrial CA

Equivalent disease-free survival at 4.5 years for stage I endometrial cancer with TAH, TLH

is free, fast, and customized just for you!

Already a member?

Sign In Now »