Zinc Effective in Pediatric Presymptomatic Wilson Disease

This article originally appeared here.
Share this content:
Zinc Effective in Pediatric Presymptomatic Wilson Disease
Zinc Effective in Pediatric Presymptomatic Wilson Disease

THURSDAY, May 4, 2017 (HealthDay News) -- For young children with presymptomatic Wilson disease, zinc monotherapy is safe and effective, according to a study published online April 28 in the Journal of Gastroenterology and Hepatology.

Keisuke Eda, from the Kurume University School of Medicine in Japan, and colleagues examined 24 children younger than 10 years with presymptomatic Wilson disease who received zinc monotherapy from the time of diagnosis.

The researchers observed a significant decrease in aspartate aminotransferase and alanine aminotransferase beginning one month after treatment initiation, and remaining under 50 U/L from one to eight years of treatment. At six months there was a significant decrease in 24-hour urinary copper, which usually remained under 75 µg/day and between 1 and 3 µg/kg/day for the rest of the study. Patients continued taking zinc and none of them became symptomatic. Aspartate aminotransferase and alanine aminotransferase significantly decreased at one month after treatment initiation in patients under 6 years who received 50 mg/day of zinc as an initial dose; at six months there were decreases in γ-glutamyltranferase and 24-hour urinary copper.

"To our knowledge, this is the first multicenter study of zinc monotherapy for young children with presymptomatic Wilson disease," the authors write. "Such monotherapy proved highly effective and safe."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »