Younger Adults Receiving Excess Anticoagulant Dosing in PCI

This article originally appeared here.
Share this content:
Younger Adults Receiving Excess Anticoagulant Dosing in PCI
Younger Adults Receiving Excess Anticoagulant Dosing in PCI

(HealthDay News) -- Many younger adults with acute myocardial infarction undergoing percutaneous coronary intervention (PCI) receive excess dosing of anticoagulants, with evidence of a trend toward an association between excess dosing and increased bleeding, according to a study published in the July 1 issue of The American Journal of Cardiology.

Aakriti Gupta, M.D., from Yale-New Haven Hospital in Connecticut, and colleagues examined the prevalence and gender-based differences of excess dosing of anticoagulants in young patients (≤55 years) with acute myocardial infarction who underwent PCI. Data were included for 2,076 patients; medical records were reviewed to abstract doses of unfractionated heparin, bivalirudin, and glycoprotein IIb/IIIa inhibitors administered during PCI.

The researchers found that at least 42.7 percent of participants received one or more excess doses of an anticoagulant, with no difference by gender. Only lower body weight and younger age were significant predictors of excess dosing in multivariable analysis. In univariable analysis, young women who received excess dosing had higher bleeding compared with those who did not (9.3 versus 6.0 percent; P = 0.03), while men had comparable bleeding with and without excess dosing (5.2 versus 5.9 percent; P = 0.69). There was a trend toward an association between excess dosing and bleeding in multivariable analysis (odds ratio, 1.33; 95 percent confidence interval, 0.92 to 1.91).

"That such a large proportion of patients receive excess doses of commonly used medications is of concern and identifies the need to develop strategies that would prevent deviance from accepted dosing guidelines," the authors write.

One author disclosed financial ties to Medtronic.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »