White Matter Damage Linked to Cognitive Impairment in CAD

This article originally appeared here.
Share this content:
White Matter Damage Linked to Cognitive Impairment in CAD
White Matter Damage Linked to Cognitive Impairment in CAD

WEDNESDAY, Sept. 7, 2016 (HealthDay News) -- In symptomatic carotid artery disease (CAD), subcortical white matter ischemic lesion locations and severity of ultrastructural tract damage contribute to cognitive impairment, according to a study published online Sept. 6 in Radiology.

Dewen Meng, from the University of Nottingham in the United Kingdom, and colleagues enrolled 108 patients with symptomatic CAD but no dementia. After controlling for age, associations between cognition, medial temporal lobe atrophy (MTA), lesion volumes, and global white matter ultrastructural damage were tested.

The researchers found that, compared with nonimpaired patients, cognitively impaired patients (49.1 percent) who were classified as having probable vascular cognitive disorder were older and had more frequent MTA, cortical infarctions, and larger volumes of acute and chronic subcortical ischemic lesions. There was no correlation for lesion volume with global cognitive performance; however, there was a correlation for cognitive performance with presence of chronic ischemic lesions within the interhemispheric tracts and thalamic radiation. Skeleton mean diffusivity was most closely correlated with cognition and had promising diagnostic accuracy for vascular cognitive disorder. In subjects with a low risk of preclinical Alzheimer's disease indexed by the absence of MTA, findings were confirmed.

"Subcortical white matter ischemic lesion locations and severity of ultrastructural tract damage contribute to cognitive impairment in symptomatic CAD, which suggests that subcortical disconnection within large-scale cognitive neural networks is a key mechanism of vascular cognitive disorder," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Price Transparency Intervention Doesn't Cut Lab Test Orders

Price Transparency Intervention Doesn't Cut Lab Test Orders

No significant changes in overall test-ordering behavior or associated fees in adjusted analyses

More Risks on School Playgrounds Linked to Happier Children

More Risks on School Playgrounds Linked to Happier ...

Greater opportunities for risk, challenge associated with fewer reports of bullying to adults

Black Men Have Higher Rate of Preclinical Prostate Cancer

Black Men Have Higher Rate of Preclinical Prostate ...

Also increased risk of progression to metastatic disease compared with the general population

is free, fast, and customized just for you!

Already a member?

Sign In Now »