White Matter Changes May ID Markers of Alzheimer's Earlier

Share this content:
White Matter Changes May ID Markers of Alzheimer's Earlier
White Matter Changes May ID Markers of Alzheimer's Earlier

WEDNESDAY, May 27, 2015 (HealthDay News) -- Damage to the brain's white matter may be an early sign of certain types of Alzheimer's disease, according to a study published online May 27 in Radiology.

Researchers used diffusion tensor magnetic resonance imaging to assess white matter in 53 people with three different types of Alzheimer's: early-onset Alzheimer's disease, logopenic variant of primary progressive aphasia, and posterior cortical atrophy.

All of the patients had extensive white matter damage, along with regional gray matter damage. "Alzheimer's is a gray matter disease. However, white matter damage has a central role in how the disease strikes and progresses," study coauthor Federica Agosta, M.D., Ph.D., from the Neuroimaging Research Unit at the San Raffaele Scientific Institute in Milan, said in a news release from the Radiological Society of North America. "The white matter damage in patients with focal Alzheimer's disease syndromes was much more severe and widespread than expected," she said. Changes in gray matter occurred in more limited areas, she added.

The findings support the theory that Alzheimer's disease may travel along white matter fibers from one area of the brain to another, according to Agosta. "In early onset Alzheimer's disease and atypical Alzheimer's disease forms, white matter degeneration may be an early marker that precedes gray matter atrophy," she said. That means that this specialized imaging technique might be able to identify people even before symptoms of Alzheimer's are apparent.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »