Weight Loss Predicts Mortality in Rheumatoid Arthritis

This article originally appeared here.
Share this content:
Weight Loss Predicts Mortality in Rheumatoid Arthritis
Weight Loss Predicts Mortality in Rheumatoid Arthritis

MONDAY, July 13, 2015 (HealthDay News) -- Weight loss is a strong predictor of mortality in patients with rheumatoid arthritis (RA), according to a study published online June 26 in Arthritis & Rheumatology.

Joshua F. Baker, M.D., from the Philadelphia Veterans Affairs (VA) Medical Center, and colleagues identified 1,674 RA patients from the VA RA Registry and analyzed their medical records to identify body mass index (BMI) at each study visit, as well as date of death, if applicable.

The researchers noted 312 deaths over 9,183 person-years. After adjusting for demographics, comorbidities, BMI, smoking, and RA therapies, a loss in BMI of ≥1 kg/m² was associated with a greater risk of death (hazard ratio [HR], 1.99; P < 0.001). After adjusting for C-reactive protein and physical function, this association remained significant (HR 1.81; P < 0.001). The greatest risk of death was seen in patients with weight loss at an annualized rate of ≥3 kg/m² (HR, 2.49; P < 0.001). Low BMI (<20 kg/m²) in patients with a history of obesity (>30 kg/m²) was also associated with a greater risk of death (HR, 8.52; P < 0.001).

"These observations may explain the observed obesity paradox and do not support a biologically protective role of obesity," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

FDA Approves 'Artificial Pancreas' for Type 1 Diabetes

FDA Approves 'Artificial Pancreas' for Type 1 Diabetes

MiniMed 670G hybrid closed loop system automatically monitors glucose, delivers insulin

More Evidence HPV Vaccine Protects Against Cervical Cancer

More Evidence HPV Vaccine Protects Against Cervical Cancer

Protection appears to occur even when only one or two of the recommended doses are given

Prescribed NSAIDs Tied to Higher Heart Failure Risk

Prescribed NSAIDs Tied to Higher Heart Failure Risk

Study of millions of health records suggests an association

is free, fast, and customized just for you!

Already a member?

Sign In Now »