Weekly Paclitaxel Doesn't Up Survival in Ovarian Cancer

Share this content:
Weekly Paclitaxel Doesn't Up Survival in Ovarian Cancer
Weekly Paclitaxel Doesn't Up Survival in Ovarian Cancer

THURSDAY, Feb. 25, 2016 (HealthDay News) -- Dose-dense weekly paclitaxel does not improve progression-free survival in ovarian cancer, according to a study published in the Feb. 25 issue of the New England Journal of Medicine.

John K. Chan M.D., from the Sutter Cancer Research Institute in San Francisco, and colleagues compared dose-dense weekly paclitaxel and carboplatin with paclitaxel and carboplatin administered every three weeks among patients with ovarian cancer. Patients were stratified according to whether they elected to receive bevacizumab and were then randomized to paclitaxel every three weeks plus carboplatin for six cycles or paclitaxel administered weekly plus carboplatin for six cycles.

The researchers found that 84 percent of the 692 patients enrolled opted to receive bevacizumab. Compared with paclitaxel administered every three weeks, weekly paclitaxel was not associated with longer progression-free survival (14.7 versus 14.0 months, respectively; hazard ratio for disease progression or death, 0.89; 95 percent confidence interval, 0.74 to 1.06). Weekly paclitaxel correlated with longer progression-free survival among patients who did not receive bevacizumab (14.2 versus 10.3 months; hazard ratio, 0.62; 95 percent confidence interval, 0.40 to 0.95); however, this was not seen among patients receiving bevacizumab (14.9 versus 14.7 months, respectively; hazard ratio, 0.99; 95 percent confidence interval, 0.83 to 1.20). There was a significant difference for treatment with versus without bevacizumab (P = 0.047).

"Weekly paclitaxel, as compared with paclitaxel administered every three weeks, did not prolong progression-free survival among patients with ovarian cancer," the authors write.

The study was partially funded by Genentech.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »