Vitamin D Treatment Has No Effect in Prediabetes

This article originally appeared here.
Share this content:
Vitamin D Treatment Has No Effect in Prediabetes
Vitamin D Treatment Has No Effect in Prediabetes

WEDNESDAY, Jan. 27, 2016 (HealthDay News) -- For patients with prediabetes or diet-treated type 2 diabetes, high-dose vitamin D treatment has no effect on β-cell function, insulin sensitivity, or glycemic control, according to a study published online Jan. 19 in Diabetes Care.

Henrik Wagner, M.D., from the Karolinska Institutet in Stockholm, and colleagues randomized 44 subjects with prediabetes or diet-controlled type 2 diabetes to 30,000 IU vitamin D3 once weekly or placebo for eight weeks. First phase (0 to 12 min) and second phase (12 to 120 min) insulin response, insulin sensitivity, and disposition index were assessed with a hyperglycemic clamp. Glucose tolerance and glycemic control were also examined.

Twenty-one subjects in the vitamin D group and 22 in the placebo group completed the study. The researchers found that the active treatment group had a two-fold increase in the season-adjusted 25-hydroxyvitamin D levels. Compared with placebo, vitamin D treatment had no effect on first-phase or second-phase insulin secretion. No group differences were seen in insulin sensitivity, disposition index, or any measures of glycemic control. Compared with placebo, there was no hypercalcemia or other adverse effects of vitamin D treatment.

"According to the findings of our study, we see no implication for vitamin D treatment to affect glucose homeostasis in subjects with abnormal glucose tolerance," the authors write.

Renapharma contributed to independent monitoring and Merck contributed study medication.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

CDC: Too Many Health Care Workers Not Getting Flu Vaccine

CDC: Too Many Health Care Workers Not Getting ...

Vaccination protects both workers and patients

Early Mobilization Improves Outcomes, LOS in Surgical ICUs

Early Mobilization Improves Outcomes, LOS in Surgical ICUs

Patients discharged sooner, become more functional when they leave the hospital

is free, fast, and customized just for you!

Already a member?

Sign In Now »