Vitamin D Shows Negative Association With ALS Progression

This article originally appeared here.
Share this content:
Vitamin D Shows Negative Association With ALS Progression
Vitamin D Shows Negative Association With ALS Progression

WEDNESDAY, July 1, 2015 (HealthDay News) -- Higher vitamin D levels were associated with a negative effect on prognosis in amyotrophic lateral sclerosis (ALS), according to a study published online June 20 in CNS Neuroscience & Therapeutics.

Hélène Blasco, Pharm.D., Ph.D., from the Université François-Rabelais in Tours, France, and colleagues prospectively collected vitamin D serum concentrations from 125 consecutive ALS patients. Levels were assessed in relation to clinical parameters and survival.

The researchers found that the mean vitamin D concentration was below the study laboratory's lower limit of normal (P < 0.0001) and did not change during the course of the disease. In patients with bulbar onset, the concentrations were higher (P = 0.003) and were negatively associated with body mass index (BMI; P = 0.0095). Vitamin D concentrations predicted worse prognosis in models with ALS Functional Rating Scale-Revised and BMI as covariates.

"Our study adds to the growing literature on the relationship between neurological disorders and hypovitaminosis D. In this study, there was a negative effect of higher vitamin D levels on the course of ALS, a finding at odds with some previous studies," the authors write. "The mechanisms underlying the relationship between vitamin D and ALS are still obscure; well-designed prospective studies are needed to better understand the involvement of vitamin D in ALS."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »