Vitamin D Doesn't Impact Insulin Sensitivity, Secretion in T2DM

Share this content:
Vitamin D Doesn't Impact Insulin Sensitivity, Secretion in T2DM
Vitamin D Doesn't Impact Insulin Sensitivity, Secretion in T2DM

WEDNESDAY, May 10, 2017 (HealthDay News) -- For patients with type 2 diabetes (T2D) and vitamin D deficiency, vitamin D supplementation has no impact on insulin sensitivity or secretion, according to a study published online May 3 in Diabetes Care.

Hanne L. Gulseth, M.D., Ph.D., from Oslo University Hospital in Norway, and colleagues examined the impact of vitamin D supplementation on insulin sensitivity and insulin secretion in 62 adults with T2D and vitamin D deficiency. Participants received a single dose of 400,000 IU oral vitamin D3 or placebo; if serum 25-hydroxyvitamin D (25[OH]D) was <100 nmol/L after four weeks, the vitamin D group received an additional 200,000 IU D3.

The researchers found that the mean serum 25(OH)D was 38.0 ± 12.6 nmol/L at baseline and increased to 96.9 ± 18.3 nmol/L, 73.2 ± 13.7 nmol/L, and 53.7 ± 9.2 nmol/L after four weeks, three months, and six months, respectively. During six months, the total exposure to 25(OH)D was 1,870 ± 192 nmol/L per week in the vitamin D group and 1,090 ± 377 nmol/L per week in the placebo group (P < 0.001). After treatment, there was no difference between or within the groups in insulin sensitivity, endogenous glucose production, or glycemic control (P = 0.52). There was no significant change after treatment in first-phase insulin secretion (P = 0.10).

"These findings do not support such use of therapeutic vitamin D3 supplementation to improve glucose homeostasis in patients with T2D," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Cost-Effectiveness of PCSK9 Inhibitors Called Into Question

Cost-Effectiveness of PCSK9 Inhibitors Called Into Question

Researchers say price would have to be between $4,000 and $5,000 per year to be cost-effective

Vitamin B6, B12 Supplements May Up Risk of Lung Cancer in Men

Vitamin B6, B12 Supplements May Up Risk of ...

Increased odds only seemed to affect men or male smokers

Tablet Use Encourages Patients to Explore Diabetes Risk

Tablet Use Encourages Patients to Explore Diabetes Risk

Replacing magazines with tablets can help patients learn about diabetes risk, take preventive action

is free, fast, and customized just for you!

Already a member?

Sign In Now »