Vitamin B-12, Folate Mitigate Reproductive Effects of DDT

This article originally appeared here.
Share this content:
Vitamin B-12, Folate Mitigate Reproductive Effects of DDT
Vitamin B-12, Folate Mitigate Reproductive Effects of DDT

(HealthDay News) -- The adverse reproductive effects of 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane (DDT) seem to be mitigated by vitamin B-12 and folate sufficiency, according to a study published in the December issue of the American Journal of Clinical Nutrition.

Fengxiu Ouyang, from the Shanghai Jiao Tong University School of Medicine, and colleagues examined whether B-vitamin sufficiency protects against the adverse effects of DDT on clinical pregnancy and subclinical early pregnancy loss. Plasma B vitamins and serum total DDT concentrations were measured in 291 nulligravid women. The authors followed the women prospectively from the time they stopped contraception until clinical pregnancy or for 12 months.

The researchers found that the incidence rates of clinical pregnancy were reduced in women with B-vitamin deficiency and a high DDT concentration compared with women with adequate B vitamins and low DDT (all P < 0.05). In women with sufficient vitamin B-12, there was no correlation between DDT and incidence of clinical pregnancy; women with vitamin B-12 deficiency had lower incidence of clinical pregnancy in association with high DDT (hazard ratio, 0.44), with the test for interaction significant (P < 0.05). In women with high DDT concentrations, the odds of early pregnancy loss decreased by 45 percent for each interquartile distance increase in folate; the test for interaction was significant (P = 0.006).

"Our results provide suggestive evidence that vitamin B-12 and folate sufficiency may help protect against adverse reproductive effects of DDT exposure," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

Congress Approves Bill Expanding Private Care for VA Patients

Congress Approves Bill Expanding Private Care for VA ...

New bill would open up access to private doctors for veterans

AAP Recommending Injectable Flu Shot for 2018-19 Flu Season

AAP Recommending Injectable Flu Shot for 2018-19 Flu ...

Children should receive injectable vaccine, which has been shown to be more consistently effective

Neurologists Identify New Type of Vertigo

Neurologists Identify New Type of Vertigo

Long-term prognosis favorable, with improvement of symptoms in more than half of patients