Very Small Brain Lesions Linked to Risk of Stroke, Death

Share this content:
Very Small Brain Lesions Linked to Risk of Stroke, Death
Very Small Brain Lesions Linked to Risk of Stroke, Death

(HealthDay News) -- Very small subclinical cerebral lesions are associated with increased risks of stroke and death, according to a study published in the July 7 issue of the Annals of Internal Medicine.

B. Gwen Windham, M.D., from the University of Mississippi Medical Center in Jackson, and colleagues examined stroke risks associated with subclinical brain lesions and white matter hyperintensities (WMHs). Data were obtained from 1,884 adults, aged 50 to 73 years, with magnetic resonance imaging, no previous stroke, and follow-up of 14.5 years.

The researchers found that, compared with no lesions, the risk of stroke was increased with lesions smaller than 3 mm only (hazard ratio, 3.47), lesions 3 mm or larger only (hazard rate, 1.94), with lesions of both sizes (hazard ratio, 8.59), and with a WMH score of at least 3 (hazard ratio, 2.14). With lesions smaller than 3 mm only and with lesions of both sizes, the risk of stroke-related death was increased (hazard ratios, 3.05 and 6.97, respectively).

"Very small cerebrovascular lesions may be associated with increased risks for stroke and death; presence of lesions smaller than 3 mm and 3 mm or larger may result in a particularly striking risk increase," the authors write. "Larger studies are needed to confirm findings and provide more precise estimates."

One author disclosed financial ties to the biotechnology industry. Several journal editors disclosed financial ties to the pharmaceutical industry.

Full text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

FDA Approves Palynziq for Phenylketonuria

FDA Approves Palynziq for Phenylketonuria

Drug is a novel enzyme therapy for adult patients with PKU with uncontrolled blood Phe concentrations

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in proportion of adults recommended for treatment; estimated decrease in CVD events, deaths