Value of Prolonged DAPT Varies With DAPT Score in PCI Patients

Share this content:
Value of Prolonged DAPT Varies With DAPT Score in PCI Patients
Value of Prolonged DAPT Varies With DAPT Score in PCI Patients

WEDNESDAY, June 14, 2017 (HealthDay News) -- For patients undergoing percutaneous coronary intervention (PCI), prolonged dual-antiplatelet therapy (DAPT) results in harm for those with low DAPT scores but reduces risk for ischemic events for those with high scores receiving paclitaxel-eluting stents, according to a study published online June 13 in the Annals of Internal Medicine.

Raffaele Piccolo, M.D., from Bern University Hospital in Switzerland, and colleagues examined the safety and efficacy of DAPT duration according to DAPT score in a randomized clinical trial. A total of 1,970 patients undergoing PCI were randomized to receive DAPT (aspirin and clopidogrel) for 24 versus six months.

The researchers found that 44.9 and 55.1 percent of patients had a DAPT score of at least 2 and a score of less than 2, respectively. Patients with high scores had a greater reduction in the primary efficacy outcome with 24- versus six-month DAPT (risk difference for score ≥2, −2.05 percentage points; risk difference for score <2, 2.91 percentage points; P = 0.030). For primary efficacy outcome, the difference by score varied by stent type; prolonged DAPT with high scores was only effective for patients with paclitaxel-eluting stents (risk difference, −7.55 percentage points). Patients with low scores had a greater increase in the primary safety outcome with 24- versus six-month DAPT (risk difference for score ≥2, 0.20 percentage points; risk difference for score <2, 2.58 percentage points; P = 0.046).

"Whether prolonged DAPT benefits patients with high scores treated with contemporary drug-eluting stents requires further study," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Zika Does Not Appear to Last in Semen As Long As Thought

Zika Does Not Appear to Last in Semen ...

More research is needed to better inform public health recommendations

Radioiodine Therapy for Thyroid Cancer Doesn't Up Stroke Risk

Radioiodine Therapy for Thyroid Cancer Doesn't Up Stroke ...

I-131 therapy group showed no significantly higher risk of ischemic or hemorrhagic stroke

Higher Odds of Infection With Reduced Kidney Function

Higher Odds of Infection With Reduced Kidney Function

Study finds excess community-acquired infections incidence in individuals with mild to severe CKD

is free, fast, and customized just for you!

Already a member?

Sign In Now »