Valproic Acid Plasma Levels Down With Concomitant Meropenem

Share this content:
Valproic Acid Plasma Levels Down With Concomitant Meropenem
Valproic Acid Plasma Levels Down With Concomitant Meropenem

THURSDAY, Feb. 9, 2017 (HealthDay News) -- Concomitant use of valproic acid (VPA) and meropenem (MEPM) is associated with a decrease in VPA plasma levels, according to a study published online Feb. 1 in the Journal of Clinical Pharmacy and Therapeutics.

Z.-P. Wen, from Xiangya Hospital in Changsha, China, and colleagues conducted a retrospective analysis of 381 VPA therapeutic drug monitoring (TDM) records. VPA plasma levels were compared in different groups to examine the change in VPA level in the drug interaction with MEPM.

The researchers found that concomitant use of VPA and MEPM was associated with considerable decreases in VPA plasma level in both the 1.2 g/day (67.3 ± 4.6 versus 15.3 ± 1.9 µg/mL; P < 0.001) and 1.6 g/day (67.6 ± 1.2 versus 18.1 ± 2.6 µg/mL; P < 0.001) VPA groups. VPA plasma concentration did not differ significantly for the 1.2, 1.6, and 2.0 g/day VPA + MEPM groups (15.3 ± 1.9 µg/mL versus 18.1 ± 2.6 µg/mL versus 9.0 ± 3.0 µg/mL; P = 0.252). The MEPM daily dose did not affect the decrease in VPA concentration (14.0 ± 5.1 µg/mL versus 16.5 ± 1.9 µg/mL for high versus low MEPM daily dose; P = 0.729). VPA plasma concentration recovered to a value comparable to that before MEPM initiation after discontinuation of MEPM for more than seven days (69.7 ± 4.2 µg/mL versus 51.2 ± 8.1 µg/mL; P = 0.48).

"Our results imply that the decrease in drug concentration cannot be reversed by increasing VPA dose," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »