Vagus Nerve Stimulation Promising in Crohn's Disease

This article originally appeared here.
Share this content:
Vagus Nerve Stimulation Promising in Crohn's Disease
Vagus Nerve Stimulation Promising in Crohn's Disease

WEDNESDAY, May 3, 2017 (HealthDay News) -- Vagus nerve stimulation may represent a new therapeutic option for patients with Crohn's disease (CD), according to a report published online April 18 in the Journal of Internal Medicine.

Noting that pharmaceutical treatment of inflammatory bowel disease (IBD) with anti-tumor necrosis factor α (TNFα) agents is beneficial but has side effects, and that some patients stop treatment or take it periodically, Bruno Bonaz, M.D., Ph.D., from the University Hospital in Grenoble, France, and colleagues discuss the potential of a nondrug therapy targeting TNFα through a physiological pathway.

The researchers note that there is an inverse correlation between vagal tone and plasma TNFα level in patients with CD. In a rat model of colitis and in a pilot study involving seven patients with moderate CD, chronic vagus nerve stimulation had anti-inflammatory properties. After three months of vagus nerve stimulation, two of these patients failed to improve, but five were in deep remission at six-month follow-up, with restoration of vagal tone. There were no major side effects.

"Vagus nerve stimulation provides a new therapeutic option in the treatment of CD," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »