Urine Metabolomics Linked to Clinical Parameters of Asthma

This article originally appeared here.
Share this content:
Urine Metabolomics Linked to Clinical Parameters of Asthma
Urine Metabolomics Linked to Clinical Parameters of Asthma

MONDAY, May 23, 2016 (HealthDay News) -- Increased urine metabolomic lipid metabolites are associated with clinical parameters in non-obese asthma patients, according to a study published online May 18 in Allergy.

Claudia Chaves Loureiro, M.D., Ph.D., from the Centro Hospitalar e Universitário de Coimbra in Portugal, and colleagues conducted an observational and exploratory study to examine the correlation between oxidative stress extension, eosinophilic inflammation, and disease severity in asthma patients. Metabolomics was performed using solid phase microextraction followed by comprehensive two-dimensional gas chromatography coupled to mass spectrometry with a high resolution time of flight analyzer.

The researchers established a reduced data set comprising 34 aliphatic alkanes and aldehydes. Obese subjects were excluded from the analysis. Significant models were seen for clinical parameters, including severity of asthma score, forced expiratory volume in one second, and Th2 inflammatory biomarkers (FeNO, blood eosinophils, and seric immunoglobulin E).

"Non-obese asthmatics had increased urine metabolomic lipid metabolites associated with clinical parameters such as lung function, eosinophilic inflammation, and severity," the authors write. "Nevertheless, considering our sample size, the obtained results require further validation using a much larger sample cohort."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Caffeine Found to Reduce Age-Related Inflammation

Caffeine Found to Reduce Age-Related Inflammation

Connection between advancing age, systemic inflammation, cardiovascular disease and caffeine

Neonatal Abstinence Syndrome Tied to Poor School Performance

Neonatal Abstinence Syndrome Tied to Poor School Performance

By seventh grade, four out of 10 failed to meet standards in at least one academic area

Heart Rate Variability Linked to Atrial Fibrillation

Heart Rate Variability Linked to Atrial Fibrillation

Lower HRV, increased sympathetic/parasympathetic tone linked to higher risk of a-fib

is free, fast, and customized just for you!

Already a member?

Sign In Now »