Urine Haptoglobin Can Predict Kidney Damage in T2DM

Share this content:
Urine Haptoglobin Can Predict Kidney Damage in T2DM
Urine Haptoglobin Can Predict Kidney Damage in T2DM

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- Urine haptoglobin is a novel biomarker for predicting kidney damage in patients with type 2 diabetes (T2D), according to a study published online Nov. 30 in Diabetes Care.

Jin-Kui Yang, M.D., Ph.D., from Capital Medical University in Beijing, and colleagues performed a shotgun urine proteomic analysis in patients with microalbuminuria (MAU) and proliferative diabetic retinopathy (PDR; cases) and in patients with MAU and T2D for more than 10 years without any retinopathy (controls). Two hundred ten patients with T2D were followed for a median of 5.3 years in the cohort study.

The researchers found that the top two proteins with the highest difference in ratio of case to control subjects were haptoglobin and α-2-macroglobulin (8.7- and 5.7-fold, respectively; both P < 0.0001). Patients with versus those without baseline urinary haptoglobin ≥20 ng/min (haptoglobinuria) had elevated incidence of chronic renal insufficiency (CRI; hazard ratio, 3.27; P = 0.006) in the cohort study. The overall CRI rate was 3.2, 9.5, and 13.3 percent, respectively, for patients with haptoglobinuria or MAU, for those with MAU, and for those with haptoglobinuria. Patients with both MAU and haptoglobinuria had the highest rate for CRI (22.4 percent; P < 0.001).

"Urine haptoglobin, which is specific for PDR, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with T2D," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

FDA Warns of Possible Heart Risks Linked to Clarithromycin

FDA Warns of Possible Heart Risks Linked to ...

Agency advising doctors to consider prescribing other antibiotics to patients with coronary heart disease

Artificial Intelligence May Help Prevent Physician Burnout

Artificial Intelligence May Help Prevent Physician Burnout

Many potential uses for AI, including improving searches and documentation, selecting treatment

Benzodiazepine Use Declining in Older Adults

Benzodiazepine Use Declining in Older Adults

Findings based on assessment of incidence, prevalence of use in three countries from 2010-2016

is free, fast, and customized just for you!

Already a member?

Sign In Now »