Uric Acid May Mark Progression for Nasopharyngeal Cancer

Share this content:
Uric Acid May Mark Progression for Nasopharyngeal Cancer
Uric Acid May Mark Progression for Nasopharyngeal Cancer

FRIDAY, Dec. 30, 2016 (HealthDay News) -- There is a direct correlation between the pretreatment serum uric acid (SUA) level and tumor progression in patients with locally advanced nasopharyngeal carcinoma (NPC), according to a study published online Dec. 20 in Head & Neck.

Xiao-Jing Du, M.D., from the Sun Yat-sen University Cancer Center in Guangzhou, China, and colleagues retrospectively examined data from 1,063 patients with locally advanced NPC to determine the predictive value of pretreatment SUA.

The researchers found that high pretreatment SUA level (>353.4 µmol/L) independently predicted distant metastasis-free survival (P = 0.013). High pretreatment SUA also was associated with high white blood cell counts (P = 0.005), lymphocyte counts (P < 0.001), and male sex (P < 0.001). SUA levels were significantly elevated in patients with T1 to T3 classification (P = 0.042). Markedly higher pretreatment SUA levels were detected for patients with subsequent lung metastases after treatment versus patients who had other distant metastases (P = 0.012) and patients without distant metastasis (P = 0.024).

"Pretreatment SUA may be a useful biomarker for evaluating treatment options for patients with locally advanced NPC," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

USPSTF Urges Abuse Screening for Reproductive-Aged Women

USPSTF Urges Abuse Screening for Reproductive-Aged Women

Evidence lacking for assessing balance of benefits, harms of screening for abuse of seniors, vulnerable

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

Five-Day Nitrofurantoin Beats Single-Dose Fosfomycin for UTI

Increased likelihood of clinical and microbiological resolution for uncomplicated UTI in women

Exercise Intervention Doesn't Improve Walking Ability in PAD

Exercise Intervention Doesn't Improve Walking Ability in PAD

Smaller mean change from baseline to follow-up in 6-minute walking distance with exercise intervention

is free, fast, and customized just for you!

Already a member?

Sign In Now »