Two Genetic Subtypes of Crohn's Disease Identified

This article originally appeared here.
Share this content:
Two Genetic Subtypes of Crohn's Disease Identified
Two Genetic Subtypes of Crohn's Disease Identified

FRIDAY, Oct. 14, 2016 (HealthDay News) -- Crohn's disease appears to have at least two distinct genetic subtypes, which could explain why the condition is so hard to treat, according to research published online Oct. 14 in Gut.

Shehzad Sheikh, M.D., Ph.D., an assistant professor in the departments of medicine and genetics at the University of North Carolina School of Medicine in Chapel Hill, and colleagues analyzed colon tissue samples from 21 Crohn's patients.

The team discovered at least two separate genetic subtypes of the disease. Each had its own pattern of gene expression and mix of clinical characteristics. These differences existed independently of patients' ages or treatment histories.

The researchers said they believe the finding could lead to more effective treatments for Crohn's. "We hope one day to be able to test Crohn's patients for the subtype of the disease they have, and thus determine which treatment should work best," Sheikh said in a university news release.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Caffeine Found to Reduce Age-Related Inflammation

Caffeine Found to Reduce Age-Related Inflammation

Connection between advancing age, systemic inflammation, cardiovascular disease and caffeine

Neonatal Abstinence Syndrome Tied to Poor School Performance

Neonatal Abstinence Syndrome Tied to Poor School Performance

By seventh grade, four out of 10 failed to meet standards in at least one academic area

Heart Rate Variability Linked to Atrial Fibrillation

Heart Rate Variability Linked to Atrial Fibrillation

Lower HRV, increased sympathetic/parasympathetic tone linked to higher risk of a-fib

is free, fast, and customized just for you!

Already a member?

Sign In Now »