Truncating Variant Prevalence Up in Peripartum Cardiomyopathy

This article originally appeared here.
Share this content:
Truncating Variant Prevalence Up in Peripartum Cardiomyopathy
Truncating Variant Prevalence Up in Peripartum Cardiomyopathy

FRIDAY, Jan. 8, 2016 (HealthDay News) -- Women with peripartum cardiomyopathy have a prevalence of truncating variants similar to that seen in patients with dilated cardiomyopathy, according to a study published online Jan. 6 in the New England Journal of Medicine.

James S. Ware, Ph.D., from Harvard Medical School in Boston, and colleagues sequenced 43 genes with variants that have been associated with dilated cardiomyopathy in 172 women with peripartum cardiomyopathy. The authors compared the prevalence of different variant types in these women with the prevalence in individuals with dilated cardiomyopathy, and with population controls.

Among the women with peripartum cardiomyopathy, the researchers identified 26 distinct, rare truncating variants in eight genes. The prevalence of truncated variants was similar to that seen in patients with dilated cardiomyopathy (15 versus 17 percent; P = 0.81), and was significantly higher than that seen in the reference population (15 versus 4.7 percent; P = 1.3 × 10−7). Two-thirds of truncating variants were identified in TTN; almost all were located in the titin A-band. Seven of the variants had been reported in patients with idiopathic dilated cardiomyopathy. The presence of TTN truncating variants correlated with lower ejection fraction at one-year follow-up in a cohort of 83 women with peripartum cardiomyopathy (P = 0.005).

"The distribution of truncating variants in a large series of women with peripartum cardiomyopathy was remarkably similar to that found in patients with idiopathic dilated cardiomyopathy," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Social, Communication Delays With False-Negative on M-CHAT

Social, Communication Delays With False-Negative on M-CHAT

Delays for those who pass M-CHAT screening at 18 months but are later diagnosed with ASD

FDA Approves Aimovig to Prevent Migraines

FDA Approves Aimovig to Prevent Migraines

Patients taking Aimovig reported one to two fewer monthly migraine days than those taking pacebo

Risk of Dementia Up for Older Adults With Lowest Wealth

Risk of Dementia Up for Older Adults With ...

Increased risk seen independent of education, index of multiple deprivation, health indicators

is free, fast, and customized just for you!

Already a member?

Sign In Now »