Transplant Recipients Have Increased Melanoma Risk

This article originally appeared here.
Share this content:
Transplant Recipients Have Increased Melanoma Risk
Transplant Recipients Have Increased Melanoma Risk

FRIDAY, Aug. 21, 2015 (HealthDay News) -- Organ transplant recipients have an increased risk of invasive melanoma, especially for regional-stage tumors, according to a study published online Aug. 13 in the Journal of Investigative Dermatology.

Hilary A. Robbins, M.S.P.H., from the National Cancer Institute in Rockville, Md., and colleagues examined the incidence of melanoma among 139,991 non-Hispanic white transplant recipients by using linked U.S. transplant-cancer registry data for 1987 to 2010. Standardized incidence ratios (SIRs) were used to compare incidence to the general population, and risk factors were assessed using incidence rate ratios (IRRs). Post-melanoma survival was compared for 182 transplant recipients and 131,358 nonrecipients.

The researchers found that the risk of invasive melanoma was elevated among transplant recipients (SIR, 2.2), especially for regional-stage tumors (SIR, 4.11). After transplantation, the risk of localized tumors was stable over time, but risk was increased with azathioprine maintenance therapy (IRR, 1.35). Within four years after transplantation, the risk of regional/distant-stage tumors peaked, and there was an increase in risk with polyclonal antibody induction therapy (IRR, 1.65). Transplant recipients had increased melanoma-specific mortality compared with nonrecipients (hazard ratio, 2.98).

"Melanoma exhibits increased incidence and aggressive behavior under transplant-related immunosuppression," the authors write. "Our findings support sun safety practices and skin screening for transplant recipients."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »