Trans-Resveratrol, Hesperetin Up Glo1 Expression, Metabolic Health

This article originally appeared here.
Share this content:
Trans-Resveratrol, Hesperetin Up Glo1 Expression, Metabolic Health
Trans-Resveratrol, Hesperetin Up Glo1 Expression, Metabolic Health

MONDAY, May 16, 2016 (HealthDay News) -- For overweight and obese subjects, trans-resveratrol (tRES) and hesperetin (HESP) coformulation increases glyoxalase 1 (Glo1) expression and produces improvements in metabolic and vascular health, according to a study published online May 11 in Diabetes.

Mingzhan Xue, M.D., Ph.D., from the University of Warwick in the United Kingdom, and colleagues screened bioactive compounds for Glo1 inducer activity in a functional reporter assay, confirmed hits in cell culture, and evaluated an optimized Glo1 inducer formulation in a randomized crossover trial involving 29 overweight and obese subjects.

The researchers found that clinically-achieved concentrations of tRES and HESP synergized to increase Glo1 expression. tRES-HESP coformulation increased expression and activity of Glo1 in highly overweight subjects, and decreased plasma methylglyoxal and total body methylglyoxal-protein glycation. In addition, tRES-HESP coformulation was associated with decreased fasting and postprandial plasma glucose, increased oral glucose insulin sensitivity index, and improved arterial dilation. Decreases were seen in vascular inflammation marker soluble intercellular adhesion molecule-1 in all subjects.

"In previous clinical evaluations, tRES and HESP individually were ineffective," the authors write. "tRES-HESP coformulation could be a suitable treatment for improved metabolic and vascular health in overweight and obese populations."

Several authors are employees of Unilever, which partially funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Insulin Glargine, Lixisenatide Combo Beneficial in T2DM

Improved achievement of glycemic targets, reduced body weight

European, American Guidelines Lead to Different Recs for Statins

European, American Guidelines Lead to Different Recs for ...

Quantification of CAC score can improve stratification for those at high, low risk for events

Hyperbaric O2 Therapy Effective in Maxillary Osteoradionecrosis

Hyperbaric O<sub>2</sub> Therapy Effective in Maxillary Osteoradionecrosis

Positive clinical outcome with HBOT for 85.7 percent of patients with maxillary bone osteoradionecrosis

is free, fast, and customized just for you!

Already a member?

Sign In Now »