Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure

This article originally appeared here.
Share this content:
Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure
Tocilizumab Treats Rheumatoid Arthritis After Non-TNFi Failure

WEDNESDAY, March 30, 2016 (HealthDay News) -- For patients with rheumatoid arthritis (RA) and a first non-tumor necrosis factor inhibitor (TNFi) failure, treatment with tocilizumab seems more efficacious than abatacept or rituximab, according to a study published online March 27 in the International Journal of Rheumatic Diseases.

Tristan Pascart, M.D., from Lille University in Lomme, France, and colleagues conducted a retrospective, multicenter study involving patients treated for RA with abatacept, rituximab, or tocilizumab after a non-TNFi failure. Data were collected for 100 patients who started a second non-TNFi between 2006 and 2013 (15 treated with rituximab, 36 with tocilizumab, and 49 with abatacept).

The researchers found that the change in Disease Activity Index of 28 joints-erythrocyte sedimentation rate (DAS28-ESR) differed significantly between the groups (P = 0.001). The decrease in DAS28-ESR was higher for patients treated with tocilizumab versus abatacept (median, 36 versus 0 percent; P = 0.002). A similar difference was seen for tocilizumab and rituximab, although the difference was not significant (median decrease, 36 versus 0 percent; P = 0.07). The results were similar for 12-month change in DAS28-C-reactive protein.

"This study suggests a better efficacy of tocilizumab compared with abatacept and rituximab in situations of non-TNFi failure," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical technology industries.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

CDC: No Change in Level of Uninsured in U.S. in 2017

CDC: No Change in Level of Uninsured in ...

Five percent of children uninsured in 2017, 41.3 and 55.0 percent had public and private coverage

Age-Related Racial Disparity Examined in Childhood Suicide

Age-Related Racial Disparity Examined in Childhood Suicide

Significantly higher incidence of suicide for black children aged 5 to 12; lower rate for black teens

Moral Distress for Docs Providing Emergency-Only Hemodialysis

Moral Distress for Docs Providing Emergency-Only Hemodialysis

Docs describe burnout and emotional exhaustion; moral distress at seeing suffering and injustice

is free, fast, and customized just for you!

Already a member?

Sign In Now »