Three Anti-VEGF Treatments Effective for Diabetic Retinopathy

Share this content:
Three Anti-VEGF Treatments Effective for Diabetic Retinopathy
Three Anti-VEGF Treatments Effective for Diabetic Retinopathy

THURSDAY, April 27, 2017 (HealthDay News) -- Three anti-vascular endothelial growth factor (anti-VEGF) treatments are associated with low rates of diabetic retinopathy (DR) worsening, according to a study published online April 27 in JAMA Ophthalmology.

Susan B. Bressler, M.D., from Johns Hopkins University, and colleagues conducted preplanned secondary analysis of data from a comparative effectiveness trial for center-involved DME in 650 participants during two years of treatment with aflibercept (2 mg), bevacizumab (1.25 mg), or ranibizumab (0.3 mg).

The researchers found that at one year, among 423 nonproliferative DR (NPDR) eyes, 44 of 141 (31.2 percent) treated with aflibercept, 29 of 131 (22.1 percent) with bevacizumab, and 57of 151 (37.7 percent) with ranibizumab had improvement of DR severity (P = 0.004 for aflibercept versus bevacizumab, P = 0.01 for ranibizumab versus bevacizumab, and P = 0.51 for aflibercept versus ranibizumab). At two years, no treatment group differences were identified. Among the 93 eyes with proliferative DR (PDR) at baseline, one-year improvement rates were 75.9 percent for aflibercept, 31.4 percent for bevacizumab, and 55.2 percent for ranibizumab (P < 0.001 for aflibercept versus bevacizumab, P = 0.09 for ranibizumab versus bevacizumab, and P = 0.02 for aflibercept versus ranibizumab). These rates and group differences were maintained at two years.

"All three anti-VEGF treatments were associated with low rates of DR worsening. These data provide additional outcomes that might be considered when choosing an anti-VEGF agent to treat DME," conclude the authors.

Several authors report financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

Non-Nutritive Sweeteners Don't Up Blood Glucose Levels

Non-Nutritive Sweeteners Don't Up Blood Glucose Levels

Concentration of NNSs decreases gradually over the course of observation after consumption

Laws Allowing Service Denial to Sexual Minorities Tied to Distress

Laws Allowing Service Denial to Sexual Minorities Tied ...

Laws permitting denial of services linked to increase in mental distress among sexual minorities

Antidepressant Prescribing Linked to Lasting Weight Gain

Antidepressant Prescribing Linked to Lasting Weight Gain

Risk of weight gain remained increased during at least six years of follow-up