Targeting Ups Nanoparticle Delivery to Graft Endothelial Cells

This article originally appeared here.
Share this content:
Targeting Ups Nanoparticle Delivery to Graft Endothelial Cells
Targeting Ups Nanoparticle Delivery to Graft Endothelial Cells

FRIDAY, Dec. 1, 2017 (HealthDay News) -- Targeting can enhance accumulation of nanoparticles (NPs) to graft endothelial cells (ECs) of human kidneys undergoing ex vivo normothermic machine perfusion (NMP), according to research published online Nov. 29 in Science Translational Medicine.

Noting that short periods of NMP provide an opportunity to deliver therapeutics directly to an organ; specifically, to the vascular ECs before transplant, Gregory T. Tietjen, Ph.D., from Yale University in New Haven, Conn., and colleagues discuss ways to improve NP accumulation within graft ECs.

The researchers found that for human kidneys undergoing NMP, surface conjugation of an anti-CD31 antibody selectively enhanced targeting of NPs to graft ECs. Targeting enhanced EC accumulation by about five- to 10-fold or more in discrete regions of the renal vasculature, based on a two-color quantitative microscopy approach. Non-specific accumulation of NPs occurred within obstructed regions of the vasculature that were poorly perfused.

"These quantitative preclinical human studies demonstrate the therapeutic potential for targeted nanomedicines delivered during ex vivo NMP," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality ...

Minority of opioid overdose survivors receive MOUD; buprenorphine, MMT linked to reduced mortality

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination ...

Pharmacies can address cost barriers to vaccination by providing vaccines at lower cost

Single Blood Sample Test May Help ID Undiagnosed Diabetes

Single Blood Sample Test May Help ID Undiagnosed ...

Single-sample confirmatory definition associated with high positive predictive value

is free, fast, and customized just for you!




Already a member?

Sign In Now »