Targeting of Tracked Tumor Foci Ups Gleason Score Upgrading

This article originally appeared here.
Share this content:
Targeting of Tracked Tumor Foci Ups Gleason Score Upgrading
Targeting of Tracked Tumor Foci Ups Gleason Score Upgrading

THURSDAY, Feb. 23, 2017 (HealthDay News) -- Targeting of tracked tumor foci allows for improved detection of Gleason score 4 + 3 or greater cancers among men under active surveillance for prostate cancer, according to a study published in the March issue of The Journal of Urology.

Nima Nassiri, M.D., from the University of California in Los Angeles, and colleagues examined the rate of upgrading to Gleason score 4 + 3 or greater in 259 prostate cancer patients who were diagnosed via magnetic resonance imaging (MRI)/ultrasound fusion guided biopsy from 2009 to 2015 and underwent fusion biopsy during active surveillance.

The researchers found that men with Gleason score 3 + 4 were 4.65 times more likely to have upgrading at three years than men with Gleason score of 3 + 3 (P < 0.01). By the third surveillance year, 63 and 18.0 percent of men with Gleason score 3 + 4 and 3 + 3, respectively, had been upgraded (P < 0.01). Ninety-seven percent of the 33 upgrades occurred at a MRI-visible or a tracked site of tumor, instead of a previously negative systematic site. Gleason score 3 + 4, prostate-specific antigen density 0.15 ng/ml/cm³ or greater, and a grade 5 lesion on MRI were independent predictors of upgrading.

"During active surveillance of prostate cancer, targeting of tracked tumor foci by MRI/ultrasound fusion biopsy allows for heightened detection of Gleason score 4 + 3 or greater cancers," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Opioid Rx, Dosing Often Excessive in Dialysis Patients

Opioid Rx, Dosing Often Excessive in Dialysis Patients

High-risk dialysis population also subject to the risks of long-term opioid use

Nonadherence to Statins  ACEIs/ARBs Risky Post MI

Nonadherence to Statins &#43; ACEIs/ARBs Risky Post MI

Adherence to beta-blockers may not be as beneficial to patients after myocardial infarction

Pulse Ox  Auscultation Reliable for Congenital Heart Screening

Pulse Ox &#43; Auscultation Reliable for Congenital Heart ...

The method significantly improves detection rate of major CHD in newborns

is free, fast, and customized just for you!

Already a member?

Sign In Now »