T2DM Risk Cut by Variant in Sulfonylurea Receptor Encoder

Share this content:
T2DM Risk Cut by Variant in Sulfonylurea Receptor Encoder
T2DM Risk Cut by Variant in Sulfonylurea Receptor Encoder

TUESDAY, April 25, 2017 (HealthDay News) -- A common missense variant in the gene encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S), which promotes closure of the target channel of sulfonylurea therapy, mimicking the effects of therapy, is associated with reduced risk of type 2 diabetes and coronary heart disease, according to a study published online April 14 in Diabetes.

Connor A. Emdin, D.Phil., from Massachusetts General Hospital in Boston, and colleagues used individual-level data from 120,286 participants in the U.K. Biobank and results from four large genome-wide association studies to examine the impact of p.A1369S on cardiometabolic traits, type 2 diabetes, and coronary heart disease.

The researchers found that there was a correlation between the p.A1369S variant and a significantly lower risk of type 2 diabetes (odds ratio, 0.93). The variant was also correlated with increased body mass index (0.062 kg/m²) but lower waist-to-hip ratio adjusted for body mass index. In addition, p.A1369S was associated with a significantly reduced risk of coronary heart disease (odds ratio, 0.98).

"These results suggest that, despite a known association with increased weight, long-term sulfonylurea therapy may reduce the risk of coronary heart disease," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Zika Does Not Appear to Last in Semen As Long As Thought

Zika Does Not Appear to Last in Semen ...

More research is needed to better inform public health recommendations

Radioiodine Therapy for Thyroid Cancer Doesn't Up Stroke Risk

Radioiodine Therapy for Thyroid Cancer Doesn't Up Stroke ...

I-131 therapy group showed no significantly higher risk of ischemic or hemorrhagic stroke

Higher Odds of Infection With Reduced Kidney Function

Higher Odds of Infection With Reduced Kidney Function

Study finds excess community-acquired infections incidence in individuals with mild to severe CKD

is free, fast, and customized just for you!

Already a member?

Sign In Now »