Sulfonylureas May Inhibit KATP Channel Neuroprotection

Share this content:
Sulfonylureas May Inhibit K<sub>ATP</sub> Channel Neuroprotection
Sulfonylureas May Inhibit KATP Channel Neuroprotection

FRIDAY, May 20, 2016 (HealthDay News) -- Treatment with sulfonylureas (ATP-sensitive potassium [KATP] channel blockers) may inhibit the neuroprotective effects of KATP channel activation and increase the risk of stroke, according to an experimental study published online May 13 in Diabetes.

Rui Liu, from the University of Toronto, and colleagues examined the effect of sulfonylureas on KATP channels and whether they impact the outcomes of stroke in diabetes.

The researchers found that there was larger brain damage and poorer behavioral outcomes for streptozotocin-induced diabetic mice subjected to transient middle cerebral artery occlusion. Neuronal injury induced by oxygen-glucose deprivation (OGD) in vitro and permanent middle cerebral artery occlusion (pMCAO) in vivo was increased by blocking KATP channel by tolbutamide. The OGD and pMCAO effects were reduced by activating KATP channel by diazoxide. Early increases were seen in protein levels of N-methyl D-aspartate receptor 2B and postsynaptic density protein-9 in streptozotocin-induced diabetic mice; there was a subsequent decrease in phosphorylation of glycogen synthase kinase 3β. The odds ratio for stroke morbidity was increased in type 2 diabetes mellitus (T2DM) patients treated with sulfonylureas versus comparator drugs in systematic meta-analysis.

"These results suggest that sulfonylurea treatment in T2DM patients may inhibit neuroprotective effects of KATP channels and increase the risk of stroke," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »