Sulfonylureas May Inhibit KATP Channel Neuroprotection

Share this content:
Sulfonylureas May Inhibit K<sub>ATP</sub> Channel Neuroprotection
Sulfonylureas May Inhibit KATP Channel Neuroprotection

FRIDAY, May 20, 2016 (HealthDay News) -- Treatment with sulfonylureas (ATP-sensitive potassium [KATP] channel blockers) may inhibit the neuroprotective effects of KATP channel activation and increase the risk of stroke, according to an experimental study published online May 13 in Diabetes.

Rui Liu, from the University of Toronto, and colleagues examined the effect of sulfonylureas on KATP channels and whether they impact the outcomes of stroke in diabetes.

The researchers found that there was larger brain damage and poorer behavioral outcomes for streptozotocin-induced diabetic mice subjected to transient middle cerebral artery occlusion. Neuronal injury induced by oxygen-glucose deprivation (OGD) in vitro and permanent middle cerebral artery occlusion (pMCAO) in vivo was increased by blocking KATP channel by tolbutamide. The OGD and pMCAO effects were reduced by activating KATP channel by diazoxide. Early increases were seen in protein levels of N-methyl D-aspartate receptor 2B and postsynaptic density protein-9 in streptozotocin-induced diabetic mice; there was a subsequent decrease in phosphorylation of glycogen synthase kinase 3β. The odds ratio for stroke morbidity was increased in type 2 diabetes mellitus (T2DM) patients treated with sulfonylureas versus comparator drugs in systematic meta-analysis.

"These results suggest that sulfonylurea treatment in T2DM patients may inhibit neuroprotective effects of KATP channels and increase the risk of stroke," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

ASCO: Moderate Activity Tied to Longer Survival in Advanced CRC

ASCO: Moderate Activity Tied to Longer Survival in ...

Patients only appeared to derive benefit from moderate -- not vigorous -- activity

Number of Infants Born to Women Using Opioids Up Sharply

Number of Infants Born to Women Using Opioids ...

Few treatment programs deal with substance abuse in expectant moms, federal report says

Hypertension Onset After Age 80 May Protect Against Dementia

Hypertension Onset After Age 80 May Protect Against ...

Association independent of antihypertensive medication use

is free, fast, and customized just for you!

Already a member?

Sign In Now »