Study IDs Two Novel Loci Linked to Insulin Sensitivity

Share this content:
Study IDs Two Novel Loci Linked to Insulin Sensitivity
Study IDs Two Novel Loci Linked to Insulin Sensitivity

WEDNESDAY, Aug. 3, 2016 (HealthDay News) -- Two novel loci have been identified that are associated with insulin sensitivity, according to a study published online July 14 in Diabetes.

Geoffrey A. Walford, M.D., from Massachusetts General Hospital in Boston, and colleagues performed a genome-wide association study of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-related traits Consortium. Discovery was performed in 16,753 individuals, and the authors attempted replication in 13,354 independent individuals for the 23 most significant novel loci. The correlation with ISI was assessed in different models.

The researchers found that in a model analyzing the combined influence of genotype effect adjusted for body mass index (BMI) and the interaction effect between the genotype and BMI, three variants reached genome-wide significance: rs13422522 (NYAP2), rs12454712 (BCL2), and rs10506418 (FAM19A2). Conditioning on the known IRS1 insulin sensitivity locus eliminated the association at NYAP2; the associations at BCL2 and FAM19A2 were independent of known cardiometabolic loci.

"In conclusion, we identified two novel loci and replicated known variants associated with insulin sensitivity," the authors write. "Further studies are needed to clarify the causal variant and function at the BCL2 and FAM19A2 loci."

Several authors disclosed financial ties to the pharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Gender Difference in Survival Seen After Radical Cystectomy

Gender Difference in Survival Seen After Radical Cystectomy

Females have worse disease-free, cancer-specific, overall survival versus males with bladder cancer

Adult Obesity Prevalence Varies With Level of Urbanization

Adult Obesity Prevalence Varies With Level of Urbanization

Increased obesity for men, women living in medium, small versus large metropolitan statistical areas

Attitudes Among Obese Are Not Aligned With Healthy Living

Attitudes Among Obese Are Not Aligned With Healthy ...

Consumers with obesity report favoring taste and value rather than health and nutrition

is free, fast, and customized just for you!




Already a member?

Sign In Now »