Study Explores Factors Linked to Successful Peanut OFC

Share this content:
Study Explores Factors Linked to Successful Peanut OFC
Study Explores Factors Linked to Successful Peanut OFC

MONDAY, Dec. 5, 2016 (HealthDay News) -- Early peanut introduction is associated with increased probability of a successful oral food challenge (OFC), with higher odds for introduction between 6 to 11 versus 4 to 6 months, according to a study published online Nov. 30 in Allergy.

Matthew Greenhawt, M.D., from the University of Colorado School of Medicine in Aurora, and colleagues conducted a secondary analysis on publicly available data from the Learning Early About Peanut Allergy study. They assessed correlations between peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduction, gender, and race.

The researchers found that the odds of successful OFC at 60 months were higher with early introduction, white race, and advancing age (odds ratios, 9.2, 2.1, and 4.8, respectively), in a multiple logistic regression model. Lower odds of peanut tolerance were seen with increasing peanut wheal size, increased baseline SCORAD score, and increased kUA/L of egg serum immunoglobulin E (odds ratios, 0.58, 0.98, and 0.99, respectively). The probability of peanut tolerance was 83 percent in the early introduction arm versus 43 percent in the avoidance group with skin prick test wheal of <4 mm. A significantly higher probability of a successful OFC was seen with peanut introduction between 6 to 11 versus 4 to 6 months.

"Peanut introduction between 6 to 11 months of age was associated with the highest rates of peanut tolerance, questioning the 'urgency' of introduction before 6 months," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Deaths, Cardiac Arrest Not Rare in Triathlon Participants

Deaths, Cardiac Arrest Not Rare in Triathlon Participants

Incidence of death or cardiac arrest 1.74 per 100,000 participants; higher incidence in men, with age

ACP Does Not Support Legalization of Assisted Suicide

ACP Does Not Support Legalization of Assisted Suicide

Legalization would affect trust in the patient-physician relationship, and in the medical profession

AAP: Epinephrine Admin Training Needed in Many Schools

AAP: Epinephrine Admin Training Needed in Many Schools

In 2015 to 2016, 2.7 percent reported that epinephrine was administered by unlicensed staff

is free, fast, and customized just for you!

Already a member?

Sign In Now »