Stronger Nocebo Effect When Inert Rx Labeled As Expensive

This article originally appeared here.
Share this content:
Stronger Nocebo Effect When Inert Rx Labeled As Expensive
Stronger Nocebo Effect When Inert Rx Labeled As Expensive

FRIDAY, Oct. 6, 2017 (HealthDay News) -- Nocebo hyperalgesia is stronger when an inert treatment is labeled as being an expensive medication rather than a cheap one, according to a study published online Oct. 5 in Science.

Alexandra Tinnermann, from the University Medical Center Hamburg-Eppendorf in Germany, and colleagues examined the impact of value information about a drug, such as the price tag, on its therapeutic effect. Forty-nine healthy people were given a treatment they were told was an anti-itch cream, but it actually contained no active ingredients. They were randomized to either a group that was told the cream was cheap or a group told it was expensive. A functional magnetic resonance imaging method was used for simultaneous activity measurements in the central pain system.

The researchers found that nocebo hyperalgesia was stronger when the treatment was labeled as an expensive medication versus a cheap medication. Neural interactions between the cortex, brainstem, and spinal cord mediated this effect. Prefrontal cortex activity, in particular, mediated the effect of value on nocebo hyperalgesia.

"Value furthermore modulated coupling between prefrontal areas, brainstem, and spinal cord, which might represent a flexible mechanism through which higher-cognitive representations, such as value, can modulate early pain processing," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Older Adults Less Likely to Have Provider-Ordered Flu Testing

Older Adults Less Likely to Have Provider-Ordered Flu ...

Presence of influenza-like illness, younger age independently predict provider-ordered testing

Nutrients in Child's First 1,000 Days Key for Neurodevelopment

Nutrients in Child's First 1,000 Days Key for ...

Nutrition in prenatal period and first two years of life affects prenatal nutrient delivery, child development

In-Office Angiolytic Laser Effective for Vocal Polyps

In-Office Angiolytic Laser Effective for Vocal Polyps

Fewer adverse events for patients treated with laser plus concurrent polypectomy than laser alone

is free, fast, and customized just for you!

Already a member?

Sign In Now »