Stromal Catalase Deficiency Linked to Thymic Atrophy

This article originally appeared here.
Share this content:
Stromal Catalase Deficiency Linked to Thymic Atrophy
Stromal Catalase Deficiency Linked to Thymic Atrophy

MONDAY, Aug. 10, 2015 (HealthDay News) -- Thymic atrophy seems to be accelerated by stromal catalase deficiency, and can be decreased by genetic complementation of catalase or chemical antioxidants, according to a study published online Aug. 6 in Cell Reports.

Noting that T lymphocytes are produced by the thymus in proportion to its size, Ann V. Griffith, Ph.D., from The Scripps Research Institute in Jupiter, Fla., and colleagues discuss the decreased output of new T cell production as the thymus atrophies with age.

The researchers found that accelerated and irreversible thymic atrophy results from stromal deficiency in the reducing enzyme catalase, which leads to increased hydrogen peroxide damage caused by aerobic metabolism. Atrophy was diminished by genetic complementation of catalase in stromal cells and by chemical antioxidants.

"We propose that irreversible thymic atrophy represents a conventional aging process that is accelerated by stromal catalase deficiency in the context of an intensely anabolic (lymphoid) environment," the authors write.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »