Steroid Avoidance May Not Help Reduce Posttransplant Diabetes

This article originally appeared here.
Share this content:
Steroid Avoidance May Not Help Reduce Posttransplant Diabetes
Steroid Avoidance May Not Help Reduce Posttransplant Diabetes

(HealthDay News) -- For kidney transplant recipients, steroid avoidance has limited impact for reducing new-onset diabetes after transplantation (NODAT), according to a study published in the July issue of the American Journal of Transplantation.

John D. Pirsch, M.D., from the University of Wisconsin in Madison, and colleagues examined whether steroid avoidance reduces the NODAT risk following kidney transplantation. Data were included from a five-year early steroid withdrawal double-blind randomized trial. Using eight definitions, the incidence, timing, and risk factors for NODAT were assessed.

The researchers found that by five years, 36.3 percent of patients on chronic corticosteroids (CCS) and 35.9 percent on early corticosteroid withdrawal (CSWD) were diagnosed with NODAT by the American Diabetes Association definition. Slightly more cases of NODAT were identified with the definition combining fasting blood glucose ≥126 mg/dL on two occasions or treatment (CCS, 39.3 percent and CSWD, 39.4 percent). The proportion of NODAT patients requiring treatment through five years posttransplant was similar (CSWD, 22.5 percent and CCS, 21.5 percent); insulin therapy was lower with CSWD than CCS (3.7 versus 11.6 percent; P = 0.049). Only age was a significant risk factor for NODAT for more than one definition in multivariate analysis.

"This prospective, randomized trial of CSWD indicates that CSWD has a limited impact in reducing NODAT when compared to low-dose prednisone (5 mg/day from month six to five years)," the authors write.

Several authors are employees of Astellas Pharma Global Development and Astellas Scientific and Medical Affairs.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

AAP: Congress Urged to Act to Prevent Firearm Deaths

AAP: Congress Urged to Act to Prevent Firearm ...

Following latest shooting, pediatricians join call for action to be taken to address firearm deaths, injury

Lung Cancer Incidence Higher for Young Women Than Young Men

Lung Cancer Incidence Higher for Young Women Than ...

Crossover in sex-specific rates among U.S. non-Hispanic whites born since 1965

E-Cigarette Flavoring Agent May Impair Airway Defense System

E-Cigarette Flavoring Agent May Impair Airway Defense System

Flavoring commonly used in e-cigarettes suppresses cilia beat frequency, lasting for 60 minutes

is free, fast, and customized just for you!

Already a member?

Sign In Now »