Stem Cells May Help Reverse Ischemic Stroke Damage

This article originally appeared here.
Share this content:
Stem Cells May Help Reverse Ischemic Stroke Damage
Stem Cells May Help Reverse Ischemic Stroke Damage

TUESDAY, Aug. 23, 2016 (HealthDay News) -- An experimental treatment combining transplanted neural stem cells with the protein 3K3A-APC shows it may be possible to reverse brain damage after a stroke, according to a study published online Aug. 22 in Nature Medicine.

In mice, the protein triggered the stem cells to become functioning neurons. "We showed that 3K3A-APC helps the grafted stem cells convert into neurons and make structural and functional connections with the host's nervous system," senior author Berislav Zlokovic, M.D., Ph.D., director of the Zilkha Neurogenetic Institute at the University of Southern California, said in a university news release. Zlokovic is also a scientific founder of ZZ Biotech, a company that is developing treatments with the protein used in this trial.

Zlokovic and his team now want to conduct a clinical trial to test whether this therapy is effective in stroke patients. If it's successful, they plan to test the therapy in treating other neurological conditions, such as spinal cord injuries.

In an ongoing clinical trial funded by the U.S. National Institutes of Health, 3K3A-APC alone is being given to patients within a few hours of ischemic stroke, to determine if the protein can help protect against brain damage.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters


More in Home

Study Finds 31 Percent Use No Opioids After Surgery

Study Finds 31 Percent Use No Opioids After ...

At discharge, 92.2 percent of patients received an opioid prescription; nearly 63 percent unused

PAs May Have Lower Diagnostic Accuracy for Melanoma

PAs May Have Lower Diagnostic Accuracy for Melanoma

PAs diagnose fewer melanomas in situ, perform more skin biopsies per case of skin cancer diagnosed

AAN: Neuromodulation Therapy Gives Relief From Hand Tremor

AAN: Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern safe for essential tremor

is free, fast, and customized just for you!

Already a member?

Sign In Now »